酒精性肝病发病机制研究的新进展

被引:80
作者
邱萍 [1 ,2 ]
李相 [1 ,2 ]
孔德松 [3 ]
曾善静 [1 ,2 ]
祖亚威 [1 ,2 ]
王允 [1 ,2 ]
潘苏华 [1 ,2 ]
机构
[1] 南京中医药大学中药学一级学科
[2] 南京中医药大学药学院
[3] 南京市中医院
关键词
酒精性肝病; 氧化应激; 脂质过氧化; 肠源性内毒素血症; 炎症; 发病机制;
D O I
暂无
中图分类号
R575 [肝及胆疾病];
学科分类号
摘要
随着酒精性肝病(ALD)发病率逐年增长,对人类健康和社会发展构成严重威胁,因此,在全世界范围内受到普遍关注。ALD的发病机制非常复杂,以往主要集中在乙醇代谢过程引起氧化应激和谷胱甘肽耗竭、营养不良、内毒素激活枯否细胞而引起相关炎症上。最新研究发现,脂代谢、肝再生和凋亡、肝脏抗氧化等多种信号转导通路、肠道菌群紊乱、细胞因子、免疫反应等多种因素参与ALD的发生发展。因此,本文将目前有关ALD最新研究进展结合国内外自然病程研究、流行现状和其它影响因素,对ALD发病机制作一综述。
引用
收藏
页码:160 / 163
页数:4
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