Pathological Relationship between Intestinal Flora and Osteoarthritis and Intervention Mechanism of Chinese Medicine

被引：0

作者：

WU Yongrong ^{[1
]}

KUANG Gaoyan ^{[2
]}

LU Fangguo ^{[3
]}

WANG Hengxin ^{[4
]}

LU Min ^{[2
]}

ZHOU Qing ^{[1
]}

机构：

[1] TAN Xin-hua Famous Medical Studio, The First Affiliated Hospital of Hunan University of Chinese Medicine

[2] Department of Orthopedics, The First Affiliated Hospital of Hunan University of Chinese Medicine

[3] Department of Medical College, Hunan University of Chinese Medicine

[4] Hinye Pharmaceutical Co, Ltd

来源：

Chinese Journal of Integrative Medicine | 2019年 / 25卷 / 09期

关键词：

osteoarthritis; intestinal flora; pathogenesis; treatment; mechanism of Chinese medicine;

D O I：

暂无

中图分类号：

R274.9 [现代医学骨伤科疾病];

学科分类号：

100508 ;

摘要：

Chinese medicine(CM) has a good clinical effect on osteoarthritis(OA), but the mechanism is not very clear. Evidence-based medicine researches have shown that intestinal flora plays a role in the pathogenesis and succession of OA. Intestinal flora affects the efficacy of CM, and CM can affect the balance of intestinal flora. This paper focuses on the relationship between intestinal flora, intestinal microenvironment, brain-gut axis, metabolic immunity and OA, and preliminarily expound the significance of intestinal flora in the pathogenesis of OA and the mechanism of CM intervention. The above discussion will be of great significance in the prevention and treatment of OA by CM from the perspective of intestinal flora.

引用

页码：716 / 720

页数：5

共 27 条

[21] Links Between the Microbiome and Bone [J].

Hernandez, Christopher J. ;

Guss, Jason D. ;

Luna, Marysol ;

Goldring, Steven R. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2016, 31 (09) :1638-1646

[22]

Argon mediates protection by interleukin‐8 suppression via a TLR2/TLR4/STAT3/NF‐κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia‐reperfusion injury in rat retina in vivo[J] . Felix Ulbrich,Teresa Lerach,Julia Biermann,Kai B. Kaufmann,Wolf A. Lagreze,Hartmut Buerkle,Torsten Loop,Ulrich Goebel.Journal of Neurochemistry . 2016 (6)

[23]

Not just loading and age: the dynamics of osteoarthritis, obesity and inflammation[J] . Flavia M Cicuttini MSc, FRACP, PhD,Anita E Wluka MB BS, FRACP, PhD.Medical Journal of Australia . 2016 (2)

[24]

Relationship between the gut microbiota, lipopolysaccharide, inflammation, and metabolic osteoarthritis development: Studies in a rat model[J] . K.H. Collins,H.A. Paul,R.A. Reimer,R.A. Seerattan,D.A. Hart,W. Herzog.Osteoarthritis and Cartilage . 2015

[25] Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes [J].

Hartstra, Annick V. ;

Bouter, Kristien E. C. ;

Backhed, Fredrik ;

Nieuwdorp, Max .

DIABETES CARE, 2015, 38 (01) :159-165

[26] The TLR2 Ligand FSL-1 and the TLR5 Ligand Flagellin Mediate Pro-Inflammatory and Pro-Labour Response via MyD88/TRAF6/NF-κB-Dependent Signalling [J].

Lim, Ratana ;

Barker, Gillian ;

Lappas, Martha .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2014, 71 (05) :401-417

[27] Analysis of the Toll-Like Receptor 2-2 (TLR2-2) and TLR4 mRNA Expression in the Intestinal Mucosal Immunity of Broilers Fed on Diets Supplemented with Nickel Chloride [J].

Wu, Bangyuan ;

Cui, Hengmin ;

Peng, Xi ;

Fang, Jing ;

Zuo, Zhicai ;

Deng, Junliang ;

Huang, Jianying .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2014, 11 (01) :657-670

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