AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination

被引：0

作者：

Chunxia Jiang ^{[1
]}

Wanqing Yang ^{[1
]}

Zhihong Fan ^{[1
]}

Peng Teng ^{[2
]}

Ruyi Mei ^{[2
]}

Junlin Yang ^{[1
]}

Aifen Yang ^{[1
]}

Mengsheng Qiu ^{[1
,3
]}

Xiaofeng Zhao ^{[1
]}

机构：

[1] Institute of Developmental and Regenerative Biology, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences,Hangzhou Normal University

[2] College of Life Sciences, Zhejiang University

[3] Department of Anatomical Sciences and Neurobiology,School of Medicine, University of Louisville

来源：

Neuroscience Bulletin | 2018年 / 34卷 / 03期

关键词：

AATYK; Differentiation; Oligodendrocytes;

D O I：

暂无

中图分类号：

R338 [神经生理学];

学科分类号：

0710 ; 071006 ;

摘要：

Oligodendrocytes(OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK(apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYKdeficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.

引用

页码：527 / 533

页数：7

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