How does stiffness of trabecular meshwork affect outflow resistance in human eyes?

被引：0

作者：

Fan Yuan ^{[1
,2
]}

Lucinda JCamras ^{[1
]}

WDaniel Stamer ^{[2
]}

David Epstein ^{[2
]}

Pedro Gonzalez ^{[2
]}

机构：

[1] Department of Biomedical Engineering,Duke University

[2] Department of Ophthalmology,Duke University

来源：

医用生物力学 | 2013年 / 28(S1)卷 / S1期

关键词：

TM; How does stiffness of trabecular meshwork affect outflow resistance in human eyes;

D O I：

10.16156/j.1004-7220.2013.s1.021

中图分类号：

R312 [医用物理学];

学科分类号：

1001 ;

摘要：

<正>Purpose Ocular hypertension is the primary risk factor for development of glaucoma and the only modifiable endpoint[1,2].Clinical trials involving thousands of patients have shown consistently that lowering intraocular pressure（IOP）in those with glaucoma,whether or not their IOP is above normal,slows vision loss.IOP elevation is the result of diminished outflow facility in the conventional outflow pathway;and the highest resistance to aqueous humor outflow resides in the juxtacanalicular tissue（JCT）layer of trabecular meshwork（TM）and the inner wall of Schlemm's canal（SC）.However,mechanisms of outflow facility decrease in glaucomatous eyes remain to be determined.

引用

收藏

页码：86 / 88

页数：3

相关论文

共 2 条

[1]

The changing paradigm of outflow resistance generation: Towards synergistic models of the JCT and inner wall endothelium [J] . Darryl R. Overby,W. Daniel Stamer,Mark Johnson.&nbsp&nbspExperimental Eye Research . 2008 (4)

[2]

Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes .2 Camras,L.J,Stamer,W.D,Epstein,D,Gonzalez,P,Yuan,F. Invest Ophthalmol Vis Sci . 2012