Can amino-functionalized carbon nanotubes carry functional nerve growth factor?

被引：0

作者：

Wen Chen ^{[1
,2
]}

Qing Xiong ^{[2
]}

Quanxia Ren ^{[2
]}

Yake Guo ^{[2
]}

Gao Li ^{[1
]}

机构：

[1] School of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

[2] School of Pharmacy, Shihezi University

来源：

NeuralRegenerationResearch | 2014年 / 9卷 / 03期

关键词：

nerve regeneration; spinal cord injury; carbon nanotubes; amino functionalization; ner-ve growth factor; cytotoxicity; biological activity; dispersibility; PC12; cells; chick embryo dorsal root ganglion; NSFC grant; neural regeneration;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Carbon nanotubes can carry protein into cells to induce biological effects. Amino-functionalized carbon nanotubes are soluble and biocompatible, have high reactivity and low toxicity, and can help promote nerve cell growth. In this study, amino-functionalized ethylenediamine-treated multi-walled carbon nanotubes were used to prepare carbon nanotubes-nerve growth factor complexes by non-covalent grafting. The physicochemical properties, cytotoxicity to PC12 and chick embryo dorsal root ganglion, and biological activity of the carbon nanotubes-nerve growth factor complexes were investigated. The results showed that amino functionalization improved carbon nanotubes-nerve growth factor complex dispersibility, reduced their toxicity to PC12 cells, and promoted PC12 cell differentiation and chick embryo dorsal root ganglion.

引用

页码：285 / 292

页数：8

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