An analytical method for Fe(Ⅱ) and Fe(Ⅲ) determination in pharmaceutical grade iron sucrose complex and sodium ferric gluconate complex

被引：5
作者：
Daniele Merli [1 ]
Antonella Profumo [1 ]
Carlo Dossi [2 ]
机构：
[1] Dipartimento di Chimica, Università degli Studi di Pavia, Via Taramelli 12/14/16, 27100 Pavia Italy
[2] Dipartimento di Scienze Teoriche ed Applicate (DSTA), Università dell'Insubria, Via Dunant, 7, 21100 Varese Italy
来源：
JournalofPharmaceuticalAnalysis | 2012年 / 2卷 / 06期
关键词：
Sodium ferric gluconate complex; Iron sucrose complex; Iron polysaccharides; Voltammetry;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A robust voltammetric method has been developed and validated for the determination of Fe(Ⅱ) and Fe(Ⅲ) in pharmaceutical iron polysaccharidic complexes. Undesirable low molecular weight iron complexes, at concentration about 3% in the pharmaceutical formulation, can be easily determined with good accuracy and precision. This methodology can be proposed as a viable, environmentally sustainable substitute for the conventional Normal Pulse Polarographic method in US Pharmacopeia, with better analytical figures of merit, and reduced Hg consumption. A deeper insight in Fe(Ⅱ) and Fe(Ⅲ) composition can be gained by the combined use of a new potentiometric technique after chemical decomposition of the complex.
引用
收藏
页码：450 / 453
页数：4
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