药源性胃肠道出血及其病理机制的研究进展

被引:6
|
作者
徐晗 [1 ,2 ]
张媛媛 [1 ,2 ]
寇俊萍 [1 ,2 ]
机构
[1] 中国药科大学中药学院中药药理与中医药系
[2] 江苏省中药评价与转化重点实验室
关键词
胃肠道出血; 机制; 信号途径; 进展;
D O I
暂无
中图分类号
R595.3 [药源性疾病];
学科分类号
1002 ; 100201 ;
摘要
药源性胃肠道出血是由于药物作用于胃肠道,引发胃肠黏膜糜烂、出血。引发胃肠道出血的常见药物包括非甾体抗炎药、抗血栓药、化疗药、抗菌药等,药物通过破坏胃肠道黏膜屏障、抑制血管生成、破坏机体凝血机制等途径诱发胃肠道出血,临床尚缺乏有效的防治办法。本文从药物临床研究现状和病理机制出发,综述了近5年国内外对药物引发胃肠道出血的研究进展,以期阐释药物引发胃肠道出血的作用特点,为发现防治药源性胃肠道出血的可能策略提供参考和线索。
引用
收藏
页码:659 / 665
页数:7
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