Influence of matrix-metalloproteinase inhibitor on the interaction between cancer cells and matrigel

被引：0
|
作者：
叶腾 [1 ]
叶方富 [2 ,3 ]
邱峰 [1 ,4 ]
机构：
[1] First Clinical Medical College,Nanchang University
[2] Beijing National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of Sciences
[3] Wenzhou Institute,University of Chinese Academy of Sciences
[4] Department of Oncology,First Affiliated Hospital of Nanchang University
来源：
ChinesePhysicsB | 2020年 / 29卷 / 06期
基金：
中国国家自然科学基金;
关键词：
cancer cells; matrigel; matrix metalloproteinase(MMP) inhibitor; migration;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
Various behaviors of cancer cells are strongly influenced by their interaction with extracellular matrices(ECM). We investigate how this interaction may be influenced if the cancer cells’ ability of secreting matrix metalloproteinases(MMPs)to degrade ECM is inhibited by adding the MMP inhibitor. We use MDA-MB-231-GFP cells as model cells and use matrigel to mimic ECM. It is found that the added MMP inhibitor significantly reduces the migration speed of cancer cells covered by matrigel but has little influence on the migration persistence and shape factor of the cells and that with the MMP inhibitor added the presence of matrigel on the top has no influence on the migration speed of the cells but increases the cells’ shape factor and migration persistence.
引用
收藏
页码：97 / 100
页数：4
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