Extremely high prevalence of Helicobacter pylori infection in Bhutan

被引：1

作者：

Ratha-korn Vilaichone ^{[1
]}

Varocha Mahachai ^{[2
]}

Seiji Shiota ^{[3
]}

Tomohisa Uchida ^{[4
]}

Thawee Ratanachu-ek ^{[5
]}

Lotay Tshering ^{[6
]}

Nguyen Lam Tung ^{[4
,7
]}

Toshio Fujioka ^{[8
]}

Masatsugu Moriyama ^{[4
]}

Yoshio Yamaoka ^{[3
,9
]}

机构：

[1] Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathumthani 12120, Thailand

[2] GI and Liver Center, Bangkok Medical Center, Bangkok 10310, Thailand 3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan

[3] Department of Gastroenterology and Hepatology, Baylor College of Medicine and Michael DeBakey Veterans Affairs Medical Center, Houston, TX 77030, United States

来源：

World Journal of Gastroenterology | 2013年 / 18期

基金：

美国国家卫生研究院;

关键词：

Helicobacter pylori; Bhutan; Prevalence;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

1002 ; 100201 ;

摘要：

AIM: To revealed the prevalence of Helicobacter pylori (H. pylori ) infection in the Bhutanese population. METHODS: We recruited a total of 372 volunteers (214 females and 158 males; mean age of 39.6 ± 14.9 years) from three Bhutanese cities (Thimphu, Punaka, and Wangdue). The status of H. pylori infection was determined based on five different tests: the rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), and serum anti H. pylori -antibody. RESULTS: The serological test showed a significantly higher positive rate compared with the CLO test, culture, histology and IHC (P < 0.001, P < 0.001, P=0.01, and P=0.01, respectively). When the subjects were considered to be H. pylori positive in the case of at least one test showing a positive result, the overall prevalence of H. pylori infection in Bhutan was 73.4%. The prevalence of H. pylori infection significantly decreased with age (P < 0.01). The prevalence of H. pylori infection was lower in Thimphu than in Punakha and Wangdue (P=0.001 and 0.06, respectively). The prevalence of H. pylori infection was significantly higher in patients with peptic ulcers than in those with gastritis (91.4% vs 71.3%, P=0.003). CONCLUSION: The high incidence of gastric cancer in Bhutan may be attributed to the high prevalence of H. pylori infection.

引用

页码：2806 / 2810

页数：5

共 5 条

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