IMMUNE TOLERANCE INDUCED BY GAMMA-RAY IRRADIATION

被引：0

作者：

练燕

王延江

粟永萍

冉新泽

艾国平

刘晓宏

郭朝华

程天民

机构：

[1] Department of Hematology & Oncology

[2] Southwest Hospital

[3] Institute of Combined Injury

[4] Third Military Medical University

[5] Third Military Medical University Chongqing

[6] Chongqing

来源：

ChineseJournalofCancerResearch | 2003年 / 02期

关键词：

Peritoneal lavage cell; Dendritic cell; Immune tolerance; Irradiation; Interleukin; 12; Morphology;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

Objective: To detect the existence of immune tolerance induced by gamma-ray irradiation. Methods: Peritoneal cells were harvested from mice subjected to 5 Gy 60Co gamma-ray total body irradiation at 3d, 7d, 15d and 30d, then their counts, morphological changes and IL-12 gene expression were investigated. Results: After irradiation, the peritoneal cells were sharply reduced, the cell morphology shifted from round-like to polymorphic and fusiform with some processes, expression of IL-12 p35 was seriously suppressed, while that of IL-12 p40 greatly enhanced. Conclusion: Our data highly suggest that the gamma-ray irradiation could potentially induce dendritic cell (DC) commitment and immune tolerance.

引用

页码：46 / 48

页数：3

共 8 条

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