Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats

被引：0

作者：

Akuodor GC ^{[1
]}

Essien AD ^{[1
]}

David-Oku E ^{[2
]}

Chilaka kC ^{[3
]}

Akpan JL ^{[4
]}

Ezeokpo B ^{[4
]}

Ezeonwumelu JOC ^{[5
]}

机构：

[1] Department of Pharmacology,College of Medical Sciences,University of Calabar

[2] Department of Biochemistry,of Medical Sciences,University of Calabar

[3] Department of Pharmacology and Therapeutic,College of Health Sciences,Nnamdi Azikiwe University

[4] Department of Pharmacology and Therapeutic,Faculty of Clinical Medicine,Ebonyi State University 5. School of Pharmacy,Kampala International University

来源：

Asian Pacific Journal of Tropical Medicine | 2013年 / 10期

关键词：

Guiera senegalensis; Aqueous extract; Ethanol; Aspirin; Stress induced gastric ulcers;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

Objective:To evaluate the effect of aqueous leaf extract of Guiera senegalensis(G.senegalensis)on gastric mucosal damage using different ulcer models.Methods:Considering the above claims,the present study was undertaken to validate the gastroprotective potential of the aqueous leaf extract of this plant against ethanol,water immersion and Aspirin induced ulcer models.Results:The leaf extract(50,100 and 200 mg/kg,p.o.)significantly(P<0.05)decreased the ulcer index in all assays used.Conclusions:The results obtained,provide strong evidence of antiulcer activity of the leaf extract of G.senegalensis and support the traditional uses of the plant for the treatment of ulcer.

引用

页码：771 / 775

页数：5

共 5 条

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[4] Densitometric Determination of Hecogenin from Agave americana Leaf Using HPTLC[J] . A. M. Ghoghari,M. Rajani. Chromatographia . 2006 (1)
[5] Attenuation of indomethacin‐ and HCl/ethanol‐induced oxidative gastric mucosa damage in rats by kolaviron, a natural biflavonoid of Garcinia kola seed[J] . S. B.Olaleye,E. O.Farombi. Phytother. Res. . 2006 (1)

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