Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell

被引：5

作者：

Hong Li ^{[1
]}

Zhe Li ^{[1
]}

YaMing Xu ^{[1
]}

Yue Wu ^{[1
]}

KangKang Yu ^{[1
]}

Can Zhang ^{[1
]}

YongHua Ji ^{[1
]}

Gang Ding ^{[2
,3
]}

FuXue Chen ^{[1
]}

机构：

[1] School of Life Sciences, Shanghai University

[2] Xinhua Hospital (Chongming) Affiliated to Shanghai Jiao Tong University Medical School

[3] Xinhua Translational Institute for Cancer Pain

来源：

NeuroscienceBulletin | 2014年 / 30卷 / 01期

关键词：

glioma; epigallocatechin-3-gallate; proliferation; apoptosis; invasion;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention.

引用

页码：67 / 73

页数：7

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