肝脏和肠道酯酶在药物代谢及新药研发中的作用

被引：5

作者：

姜金方

李秀立

陈笑艳

钟大放

机构：

[1] 中国科学院上海药物研究所

来源：

药学学报 | 2018年 / 02期

关键词：

羧酸酯酶; 芳基乙酰胺脱乙酰酶; 药物代谢; 药物研发;

D O I：

10.16438/j.0513-4870.2017-0823

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

人羧酸酯酶(human carboxylesterase,CES)和芳基乙酰胺脱乙酰酶(arylacetamide deacetylase,AADAC)是丝氨酸水解酶多基因家族的重要成员,不仅参与人体内源性胆固醇酯等的水解过程,还广泛参与药物在体内的代谢、活化和解毒过程,与酯类药物的个性化安全用药息息相关。本综述围绕人体内与药物代谢关系密切的酯酶,总结其结构及分布、代谢特点及近年来的研究进展,为新药研发和合理药物设计提供参考。

引用

页码：177 / 185

页数：9

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