Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii

被引：0

作者：

LI Wei-Xian ^{[1
]}

XU Wen-Jun ^{[1
]}

LUO Jun ^{[1
]}

YANG Lei ^{[1
]}

KONG Ling-Yi ^{[1
]}

机构：

[1] Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University

来源：

Chinese Journal of Natural Medicines | 2021年 / 19卷 / 05期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

D O I：

暂无

中图分类号：

O629 [天然化合物];

学科分类号：

070303 ; 081704 ;

摘要：

Two new type B polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2) and a known biogenetic precursor hyperbeanol Q(3) were isolated from the root extract of Hypericum beanii, a medicinal plant widespread in southwest China. Their chemical structures were elucidated by 1 D/2 D NMR and HRESIMS data analysis, and absolute configurations were determined through detailed electric circular dichroism(ECD) analysis including ECD exciton chirality, Mo2(OAc)4-induced ECD, and ECD comparison. Of these compounds, hyperbeone A(1) is a typical [3.3.1]-type B PPAP with an unusual C-1 geranyl side chain, and hyperberin C(2) possesses a rare bicyclo[5.3.1]hendecane core. Taking compound 3 as a starting point, a plausible biosynthetic pathway to the bicyclic type B frameworks of 1 and 2 was proposed.

引用

页码：385 / 390

页数：6

共 17 条

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