BMS-345541 inhibited nuclear factor kappa B expression and improved locomotor function recovery in rats after acute spinal cord injury

被引：0

作者：

Xin HanShouyu WangZhen ZhangDecheng LHairun Liu Department of Orthopedic SurgeryFirst Affiliated Hospital of Dalian Medical UniversityDalian Liaoning ProvinceChina ^{[116000
]}

机构：

来源：

NeuralRegenerationResearch | 2011年 / 6卷 / 23期

关键词：

spinal cord injury; BMS-345541; nuclear factor kappa B; locomotor function; neural regeneration;

D O I：

暂无

中图分类号：

R651.2 [脊髓];

学科分类号：

1002 ; 100210 ;

摘要：

This study sought to elucidate the changes of nuclear factor kappa B (NF-κB) expression and locomotor function of hind limb after subdural injection of BMS-345541 was applied in rats with acute spinal cord injury.The results indicated that BMS-345541 treatment reduced the expression of NF-kB at 24 hours after injury,compared with normal saline-tre ated rats.This treatment also led to a significant improvement in locomotor functional recovery at 14 days after injury.Overall,the findings demonstrated that BMS-345541 significantly ameliorated spinal cord injury-induced hind limb dysfunction by inhibiting the expression of NF-kB after spinal cord injury.

引用

页码：1775 / 1779

页数：5

共 11 条

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