Influence of Tanshinone lla on heat shock protein 70,Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury

被引:10
作者
Li Zhang
Weidong Gan
Guoyao An
机构
[1] SchoolofTraumatologyandOrthopedics,FujianUniversityofTraditionalChineseMedicine
关键词
Tanshinone lla; Danshen; spinal ischemia/reperfusion injury; heat shock protein 70; Bcl-2; Bax; cell apoptosis; Chinese medicine; neural regeneration;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
1008 ;
摘要
Tanshinone lla is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone lla can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone lla promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone lla, compared with positive control Danshen injection.
引用
收藏
页码:2882 / 2888
页数:7
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