Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes

被引：0

作者：

WANG XiaoHe ^{[1
,2
]}

DAI Ce ^{[2
]}

WANG Jun ^{[2
]}

LIU Rui ^{[2
]}

LI Lei ^{[2
]}

YIN ZongSheng ^{[2
]}

机构：

[1] Department of Bone and Joint Surgery, Institute of Orthopedic Diseases, the First Affiliated Hospital, Jinan University

[2] Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University

来源：

Chinese Journal of Natural Medicines | 2021年 / 19卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

During the pathogensis of rheumatoid arthritis(RA), activated RA fibroblast-like synoviocytes(RA-FLSs) combines similar proliferative features as tumor and inflammatory features as osteoarthritis, which eventually leads to joint erosion. Therefore, it is imperative to research and develop new compounds, which can effectively inhibit abnormal activation of RA-FLSs and retard RA progression. Neohesperidin(Neo) is a major active component of flavonoid compounds with anti-inflammation and anti-oxidant properties. In this study, the anti-inflammation, anti-migration, anti-invasion, anti-oxidant and apoptosis-induced effects of Neo on RAFLSs were explored to investigate the underlying mechanism. The results suggested that Neo decreased the levels of interleukin IL-1β,IL-6, IL-8, TNF-α, MMP-3, MMP-9 and MMP-13 in FLSs. Moreover, Neo blocked the activation of the MAPK signaling pathway.Furthermore, treatment with Neo induced the apoptosis of FLSs, and inhibited the migration of FLSs. It was also found that Neo reduced the accumulation of reactive oxygen species(ROS) induced by TNF-α. Taken together, our results highlighted that Neo may act as a potential and promising therapeutic drug for the management of RA.

引用

页码：741 / 749

页数：9

共 40 条

[1] TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation [J].

Al-Azab, Mahmoud ;

Qaed, Eskandar ;

Ouyang, Xunli ;

Elkhider, Abdalkhalig ;

Walana, Williams ;

Li, Han ;

Li, Weiping ;

Tang, Yawei ;

Adlat, Salah ;

Wei, Jing ;

Wang, Bing ;

Li, Xia .

FEBS JOURNAL, 2020, 287 (14) :3088-3104

[2] Isolation and characterization of flavonoids from the roots of medicinal plantTadehagi triquetrum(L.) H.Ohashi [J].

Vedpal ;

Jayaram, Unni ;

Wadhwani, Ashish ;

Dhanabal, S. P. .

NATURAL PRODUCT RESEARCH, 2020, 34 (13) :1913-1918

[3] The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of Saccharomyces Cerevisiae BY4742 [J].

Guo, Chunxia ;

Zhang, Hua ;

Guan, Xin ;

Zhou, Zhiqin .

MOLECULES, 2019, 24 (22)

[4]

Neohesperidin prevents colorectal tumorigenesis by altering the gut microbiota[J] . Yanling Gong,Rong Dong,Xiaomeng Gao,Jin Li,Li Jiang,Jiale Zheng,Sunliang Cui,Meidan Ying,Bo Yang,Ji Cao,Qiaojun He.Pharmacological Research . 2019

[5]

A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway[J] . Hongyan Du,Xi Zhang,Yongchang Zeng,Xiaoming Huang,Hao Chen,Suihai Wang,Jing Wu,Qiang Li,Wei Zhu,Hongwei Li,Tiancai Liu,Qinghong Yu,Yingsong Wu,Ligang Jie.Frontiers in Immunology . 2019

[6]

MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth[J] . J.D. O’Neil,A.J. Ammit,A.R. Clark.International Journal of Biochemistry and Cell Bi . 2018

[7]

Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies[J] . Itoh Yoshifumi.Progress in molecular biology and translational science . 2017

[8] ROS-modulated therapeutic approaches in cancer treatment [J].