Preparation and antibacterial activities of metal complexes of norfloxacin

被引：0

作者：

Ahsan Zamir Siddiqi ^{[1
,2
]}

Muneeba Akhtar ^{[3
]}

Agha Zeeshan Mirza ^{[4
]}

机构：

[1] Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi

[2] Department of Pharmaceutics, Faculty of Pharmacy, University of Central Punjab

[3] Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University

来源：

JournalofChinesePharmaceuticalSciences | 2021年 / 30卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R943 [制剂学];

学科分类号：

摘要：

The metal complexes of norfloxacin were prepared, and their structures were characterized using spectroscopic techniques like IR,;H NMR, UV, atomic absorption, and CHN analysis. The solubility, melting point, and conductance measurements were also performed. These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom. The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method. It was observed that the complexes of norfloxacin with magnesium, calcium, cobalt, nickel, and copper showed improved activity compared with the stated drug.

引用

页码：838 / 844

页数：7

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