Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus

被引：0

作者：

Wangxin Zhang ^{[1
,2
]}

Qiuling Zhang ^{[2
]}

Wen Deng ^{[2
]}

Yalu Li ^{[2
]}

Guoqing Xing ^{[2
]}

Xianjun Shi ^{[2
]}

Yifeng Du ^{[1
]}

机构：

[1] Department of Neurology,Shandong Provincial Hospital,Shandong University

[2] Department of Medical Psychology,Taishan Medical University

来源：

NeuralRegenerationResearch | 2014年 / 9卷 / 15期

关键词：

nerve regeneration; cerebral ischemia/reperfusion; ganoderma lucidum; anti-oxidative; anti-inflammatory; superoxide dismutase; malondialdehyde; interleukin-8; tumor necrosis factor-α; apoptosis; hippocampus; neural regeneration;

D O I：

暂无

中图分类号：

R743.31 [短暂性脑缺血];

学科分类号：

1002 ;

摘要：

Ganoderma lucidum is a traditional Chinese medicine,which has been shown to have both anti-oxidative and anti-inflammatory effects,and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex.This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum(by intragastric administration)in cerebral ischemia/reperfusion injury in rats.Our results showed that pretreatment with ganoder-ma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus,diminished the content of malondialdehyde in the hippocampus and serum,decreased the levels of tumor necrosis fac-tor-αand interleukin-8 in the hippocampus,and increased the activity of superoxide dismutase in the hippocampus and serum.These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and an-ti-inflammatory actions.

引用

页码：1446 / 1452

页数：7

共 14 条

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