von Willebrand Factor and von Willebrand Disease

被引：1

作者：

王兆钺

机构：

[1] JiangsuInstituteofHematologyTheFirstAffiliatedHospitalofSuzhouUniversity

来源：

血栓与止血学 | 2005年 / 04期

关键词：

von WiUebrand factor; von Willebrand factor -cleaving protease; yon Willebrand disease;

D O I：

暂无

中图分类号：

R55 [血液及淋巴系疾病];

学科分类号：

摘要：

<正>von Willebrand factor (vWF) is an important compound in the human plasma. which is synthesized by endotlrelial cells and also by megakaryocytes. The gene for vWF is located near the tip of the short arm of chromosome 12, being approximately 180 kb in length and consisting of 52 exons separated by 51 introns. The mature vWF subunit consists of 2 050 amino acid residues with molecular weight of about 250 ku. In plasma vWF appears as various multimers. vWF has two well-character-

引用

页码：147 / 149

页数：3