Serum and glucocorticoid inducible protein kinases(SGKs):a potential target for cancer intervention

被引：4
作者：
Rajesh Basnet [1 ,2 ]
Grace Qun Gong [1 ,3 ]
Chenyao Li [1 ,2 ]
Ming-Wei Wang [1 ,2 ,4 ]
机构：
[1] The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica,Chinese Academy of Sciences (CAS)
[2] University of Chinese Academy of Sciences
[3] Department of Molecular Medicine and Pathology, The University of Auckland
[4] School of Pharmacy, Fudan University
来源：
Acta Pharmaceutica Sinica B | 2018年 / 8卷 / 05期
关键词：
SGK; AKT; PI3K; Cancer; Signalling; Kinase; Inhibitor;
D O I：
暂无
中图分类号：
R91 [药物基础科学];
学科分类号：
1007 ;
摘要：
The serum and glucocorticoid inducible protein kinase(SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase(PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs(particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.
引用
收藏
页码：767 / 771
页数：5
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