Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis

被引：3

作者：

Catherine CHANG

Ruhong DONG

Akira MIYAZAKI

Naomi SAKASHITASecond Department of Pathology

Jay LIU

Michael GUO

机构：

[1] Japan

[2] New Hampshire 03755 USA

[3] Hanover

[4] Tokyo

[5] Department of Biochemistry Dartmouth Medical School

[6] Showa University School of Medicine

来源：

Acta Biochimica et Biophysica Sinica | 2006年 / 03期

关键词：

acyl-CoA; cholesterol acyltransferase; cholesterol; cholesteryl ester; atherosclerosis;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl estersfrom cholesterol and long-chain fatty-acyl-coenzyme A.At the single-cell level,ACAT serves as a regulatorof intracellular cholesterol homeostasis.In addition,ACAT supplies cholesteryl esters for lipoproteinassembly in the liver and small intestine.Under pathological conditions,the accumulation of cholesterylesters produced by ACAT in macrophages contributes to foam cell formation,a hallmark of the earlystage of atherosclerosis.Several reviews addressing various aspects of ACAT and ACAT inhibitors areavailable [1-8].This review briefly outlines the current knowledge on the biochemical properties of humanACATs,and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventionsagainst atherosclerosis.

引用

页码：151 / 156

页数：6