乌司他丁保护百草枯中毒大鼠肺免受损伤的作用

被引：19
作者：
陈达
张洪颖
贾浩
朱杰
机构：
[1] 中国医科大学附属第四医院急诊科
来源：
中国病理生理杂志 | 2015年 / 31卷 / 01期
关键词：
乌司他丁; 急性肺损伤; 百草枯; 丝裂原活化蛋白激酶; 金属蛋白酶组织抑制物; 基质金属蛋白酶;
D O I：
暂无
中图分类号：
R595.4 [药物中毒];
学科分类号：
摘要：
目的:探讨乌司他丁保护百草枯中毒大鼠肺免受损伤的作用及其机制。方法:Wistar大鼠108只,随机分为对照组、百草枯组和乌司他丁组。百草枯组和乌司他丁组给予百草枯灌胃染毒,对照组给予无菌生理盐水灌胃,乌司他丁组同时给予乌司他丁治疗。1、3、7、14、21、28 d测血清中的MDA、SOD、IL-6、IL-10和TNF-α水平,以及肺组织中的p38 MAPK、MMP-2和TIMP-1表达水平。结果:1、3、7 d百草枯组和乌司他丁组的SOD均较对照组下降(P<0.01),乌司他丁组SOD明显高于百草枯组(P<0.05)。1、3、7 d百草枯组和乌司他丁组的MDA、IL-6、IL-10及TNF-α均较对照组增高(P<0.01),乌司他丁组各指标明显低于百草枯组(P<0.05)。1、3、7、14、21、28d百草枯组和乌司他丁组肺组织中的p38 MAPK及TIMP-1均较对照组增高(P<0.01),乌司他丁组各指标明显低于百草枯组(P<0.05)。1、3、7、14、21 d百草枯组和乌司他丁组肺组织中的MMP-2均较对照组增高(P<0.01),乌司他丁组MMP-2明显低于百草枯组(P<0.05)。结论:乌司他丁通过抑制p38 MAPK信号通路及抗炎、抗氧化作用保护百草枯中毒大鼠肺免受损伤的作用。
引用
收藏
页码：166 / 171
页数：6
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共 8 条
  • [1] Induction of Protection against Paraquat-induced Oxidative Damage by Abscisic Acid in Maize Leaves is Mediated through Mitogen-activated Protein Kinase[J]. Hai-Dong Ding1,2, Xiao-Hua Zhang1, Shu-Cheng Xu3, Li-Li Sun1, Ming-Yi Jiang1,4, A-Ying Zhang1 and Yin-Gen Jin2 (1College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China;2College of Biosciences and Biotechnology, Yangzhou University, Yangzhou 225009, China;3College of Life Sciences, Fuyang Teachers College, Fuyang 2360
  • [2] Function of the p38MAPK-HSP27 Pathway in Rat Lung Injury Induced by Acute Ischemic Kidney Injury[J] . Tao Ma,Xiao Wei Liu,Zhi Liu,Nathan A. Ellis.BioMed Research International . 2013
  • [3] Effect of pirfenidone on pulmonary fibrosis due to paraquat poisoning in rats
    Seifirad, Soroush
    Keshavarz, Amirhossein
    Taslimi, Shervin
    Aran, Shima
    Abbasi, Hamidreza
    Ghaffari, Alireza
    [J]. CLINICAL TOXICOLOGY, 2012, 50 (08) : 754 - 758
  • [4] Effects of RNA interference-induced Smad3 gene silencing on pulmonary fibrosis caused by paraquat in mice
    Dong, Xue-Song
    Hu, Xiao-Bin
    Liu, Wei
    Sun, Yu-Qiang
    Liu, Zhi
    [J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2012, 237 (05) : 548 - 555
  • [5] Effects of Urinary Trypsin Inhibitor on Lipopolysaccharide-Induced Acute Lung Injury in Rabbits
    Bae, Hong-Beom
    Jeong, Cheol-Won
    Li, Mei
    Kim, Hyung-Seok
    Kwak, Sang-Hyun
    [J]. INFLAMMATION, 2012, 35 (01) : 176 - 182
  • [6] Unbalanced MMP/TIMP-1 expression during the development of experimental pulmonary fibrosis with acute paraquat poisoning
    Wang, Bo-Liang
    Tu, Yan-Yang
    Fu, Jian-Fang
    Zhong, Yue-Xia
    Fu, Guo-Qiang
    Tian, Xiao-Xi
    Wang, Li-He
    Gong, Li
    Ren, Qin-You
    [J]. MOLECULAR MEDICINE REPORTS, 2011, 4 (02) : 243 - 248
  • [7] Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts[J] . Jai-Nien Tung,Yaw-Dong Lang,Leng-Fang Wang,Chung-Ming Chen.Toxicology in Vitro . 2009 (3)
  • [8] Effect of Ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes[J] . Koji Ito,Akio Mizutani,Shinitiro Kira,Masakazu Mori,Hideo Iwasaka,Takayuki Noguchi.Injury . 2004 (3)
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