正畸力作用下压力侧牙周组织中RIP1、RIP3和MLKL的表达

被引：5

作者：

张敏杰

张苗苗

季开心

陈思言

机构：

[1] 哈尔滨医科大学附属口腔医院正畸科

来源：

口腔医学研究 | 2021年 / 37卷 / 10期

关键词：

正畸; 牙齿移动; 牙周组织改建; 压力侧;

D O I：

10.13701/j.cnki.kqyxyj.2021.10.009

中图分类号：

R783.5 [口腔正畸学];

学科分类号：

摘要：

目的:RIP1、RIP3和MLKL是坏死性凋亡主要的蛋白因子,在引起细胞死亡及炎症反应中起到重要的作用,本实验旨在研究大鼠正畸牙齿移动过程中压力侧牙周组织内RIP1、RIP3和MLKL的表达变化,探索其在压力侧牙周组织改建中的作用。方法:选取30只健康雄性SD大鼠为研究对象,随机分为6组:0 d、1 d、3 d、5 d、7 d、14 d组,每组5只,0 d组为空白对照组,以上颌两中切牙为支抗,镍钛拉簧拉左侧第一磨牙向前,力值为50 g。在各时间点处死大鼠后取其第一磨牙及周围牙周组织,免疫组织化学法检测压力侧RIP1、RIP3和MLKL的表达水平。结果:与空白对照组比较,实验组中RIP1、RIP3和MLKL的表达增加,表达趋势相似均为先升高后下降,但RIP1的表达在3 d、5 d、7 d时增加明显(P<0.05),RIP3的表达在3 d、5 d时增加明显(P<0.05),而MLKL的表达在5 d时增加明显(P<0.05)。结论:正畸牙齿移动过程中压力侧存在坏死性凋亡,RIP1、RIP3和MLKL参与正畸牙齿移动过程中压力侧牙周组织的改建。

引用

页码：906 / 909

页数：4

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