EFFECT OF TASPINE ON WOUND HEALING AND FIBROBLASTPROLIFERATION

被引：0

作者：

董亚琳

贺浪冲

陈方

机构：

[1] DepartmentofPharmacology,MedicalSchoolofXi'anJiaotongUniversity,Xi'an,China,DepartmentofPharmacology,MedicalSchoolofXi'anJiaotongUniversity,Xi'an,China,DepartmentofPharmacology,MedicalSchoolofXi'anJiaotongUniversity,Xi'an,China

来源：

Academic Journal of Xi'an Jiaotong University | 2005年 / 01期

关键词：

leontice robustum; taspine; fibroblast; wound healing;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

Objective To study the effect and mechanism of taspine on wound healing and fibroblast proliferation. Methods The effect of taspine on skin wound was observed in vivo. The different concentration of taspine hydrochloride was added to L 929 fibroblast cultivated in vitro, and lactate dehydrogenase was detected and MTT method was applied to observe effect of taspine on fibroblast proliferation. Results The local application of taspine 3mg/mL and 1.5mg/mL accelerated the healing of skin wounded. In vitro, 0.01～0.5μg/mL of taspine hydrochloride showed no effect on the change of lactate dehydrogenase activity and fibroblast proliferation. Conclusion Taspine is a kind of active alkaloid from leontice robustum which can enhance wound healing, its mechanism on wound healing is not by means of accelerating the proliferation of fibroblast, other mechanisms are necessary for being further studied.

引用

页码：75 / 79

页数：5