Imaging mass spectrometry: a molecular microscope for studying the role of lipids in Parkinson's disease

被引：0
|
作者：
Vinata Vedam-Mai [1 ]
Jacob M.Samuel [2 ]
Boone M.Prentice [2 ]
机构：
[1] Department of Neurology, University of Florida
[2] Department of Chemistry, University of Florida
来源：
Neural Regeneration Research | 2024年 / 06期
关键词：
D O I：
暂无
中图分类号：
R742.5 [震颤麻痹综合征];
学科分类号：
1002 ;
摘要：
Parkinson’s disease–A lipidopathy? The histopathological hallmark of Parkinson’s disease(PD) and dementia with Lewy bodies are inclusions enriched in α-synuclein(α-syn), known as Lewy bodies, which are not only composed of proteins, but also a core of lipid species. PD has been thus far principally thought of as a “proteinopathy” caused by the misfolding of α-syn. However,
引用
收藏
页码：1179 / 1180
页数：2
相关论文
共 50 条
  • [21] Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
    Gonzalez de San Roman, E.
    Manuel, I.
    Giralt, M. T.
    Ferrer, I.
    Rodriguez-Puertas, R.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2017, 1859 (09): : 1604 - 1614
  • [22] An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington's disease caudate nucleus
    Hunter, Mandana
    Demarais, Nicholas J.
    Faull, Richard L. M.
    Grey, Angus C.
    Curtis, Maurice A.
    JOURNAL OF NEUROCHEMISTRY, 2021, 157 (06) : 2158 - 2172
  • [23] Imaging mass spectrometry (IMS) of cortical lipids from preclinical to severe stages of Alzheimer's disease
    Rodriguez-Puertas, R.
    de San Roman, E. G.
    Manuel, I.
    Martinez-Gardeazabal, J.
    Llorente, A.
    Moreno, M.
    Lombardero, L.
    Ferrer, I.
    Teresa Giralt, M.
    JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 328 - 328
  • [24] The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease
    Galvagnion, Celine
    JOURNAL OF PARKINSONS DISEASE, 2017, 7 (03) : 433 - 450
  • [25] Mass spectrometry imaging: Towards a lipid microscope?
    Touboul, David
    Brunelle, Alain
    Laprevote, Olivier
    BIOCHIMIE, 2011, 93 (01) : 113 - 119
  • [26] Imaging lipids with secondary ion mass spectrometry
    Kraft, Mary L.
    Klitzing, Haley A.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2014, 1841 (08): : 1108 - 1119
  • [27] Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging
    Kiss, Andras
    Smith, Donald F.
    Jungmann, Julia H.
    Heeren, Ron M. A.
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2013, 27 (24) : 2745 - 2750
  • [28] Molecular Imaging Mass Spectrometry
    Josic, Dj.
    Kovac, S.
    KEMIJA U INDUSTRIJI-JOURNAL OF CHEMISTS AND CHEMICAL ENGINEERS, 2009, 58 (05): : 207 - 213
  • [29] PET Molecular Imaging in Familial Parkinson's Disease
    Matarazzo, Michele
    Wile, Daryl
    Mackenzie, Melissa
    Stoessl, A. Jon
    IMAGING IN MOVEMENT DISORDERS: IMAGING IN ATYPICAL PARKINSONISM AND FAMILIAL MOVEMENT DISORDERS, 2018, 142 : 177 - 223
  • [30] SPECT Molecular Imaging in Familial Parkinson's Disease
    Varrone, Andrea
    Pellecchia, Maria Teresa
    IMAGING IN MOVEMENT DISORDERS: IMAGING IN ATYPICAL PARKINSONISM AND FAMILIAL MOVEMENT DISORDERS, 2018, 142 : 225 - 260
12345