Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response

被引：0

作者：

Kate S O'Connor ^{[1
]}

Jacob George ^{[2
]}

David Booth ^{[1
]}

Golo Ahlenstiel ^{[2
]}

机构：

[1] Institute for Immunology and Allergy Research,Westmead Millennium Institute,University of Sydney,Sydney,NSW 2145,Australia

[2] Storr Liver Unit,Westmead Millennium Institute and Westmead Hospital,University of Sydney,Sydney,NSW 2145,Australia

来源：

World Journal of Gastroenterology | 2014年 / 20卷 / 47期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

Hepatitis C virus; Interferon lambda 3; Dendritic cells; Plasmacytoid dendritic cells; Myeloid dendritic cells; Innate immunity;

D O I：

暂无

中图分类号：

R512.63 [];

学科分类号：

100401 ;

摘要：

Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)infection.Since then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype effect.Dendritic cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is emerging.Reports have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV infection.Given the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general.

引用

页码：17830 / 17838

页数：9

共 30 条

[21]

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC. Lauterbach Henning,Bathke Barbara,Gilles Stefanie,Traidl-Hoffmann Claudia,Luber Christian A,Fejer Gyrgy,Freudenberg Marina A,Davey Gayle M,Vremec David,Kallies Axel,Wu Li,Shortman Ken,Chaplin Paul,Suter Mark,O’Keeffe Meredith,Hochrein Hubertus. The Journal of experimental medicine . 2010

[22]

Modulation of human plasmacytoid DC function by IFN-lambda1 （IL-29）. Megjugorac Nicholas J,Gallagher Grant E,Gallagher Grant. Journal of Leukocyte Biology . 2009

[23]

Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of alpha interferon. Cicinnati Vito R,Kang Jinyu,Sotiropoulos Georgios C,Hilgard Philip,Frilling Andrea,Broelsch Christoph E,Gerken Guido,Beckebaum Susanne. The Journal of general virology . 2008

[24]

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence[J] . Rehermann,Barbara.Journal of Clinical Investigation . 2009 (7)

[25] Antigen crosspresentation by human plasmacytoid dendritic cells [J].