Albumin for fluid resuscitation in patients with sepsis:what do we expect for?

Without adequate fluid replacement,patients with sepsis often experienced serious hypovolemia due to fever,vomiting,or diarrhea before admission.To make things worse,relative and absolute intravascular volume deficits could be exacerbated by sepsis-induced vasodilation,increased microvascular permeability and abnormal distribution of blood flow.;Consequently,it led to poor tissue perfusion and facilitated the development of multiple organ failure.Therefore,fluid resuscitation is crucial for initial management of severe sepsis,by which the restoration and maintenance of adequate intravascular volume contribute greatly to hemodynamic stability,and attenuate poor perfusion-caused organ injuries.;However,the choice of fluid remains controversial.