Multisystem inflammatory syndrome in children (MIS-C) with secondary intestinal cytomegalovirus infection: A case report

被引：0

作者：

Li, Chunqiao ^{[1
]}

Zhang, Tianlei ^{[1
]}

Xie, Youjun ^{[1
,2
]}

Wei, Rong ^{[1
,2
]}

Wu, Wenbiao ^{[1
,2
]}

机构：

[1] Guangxi Univ Chinese Med, Nanning 530000, Peoples R China

[2] Guangxi Zhuang Autonomous Reg Maternal & Child Hlt, Crit Care Med, Nanning 530000, Peoples R China

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2025年 / 113卷 / 04期

关键词：

Cytomegalovirus; MIS-C; SARS-CoV-2;

D O I：

10.1016/j.diagmicrobio.2025.117038

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Multisystem inflammatory syndrome in children (MIS-C) constitutes a severe pediatric disorder temporally linked to SARS-CoV-2 infection. Although SARS-CoV-2 may induce cytomegalovirus (CMV) reactivation, MIS-C cases with secondary intestinal CMV infection are exceptionally rare. We describe a pediatric patient with MIS-C treated initially with intravenous immunoglobulin (IVIG) and methylprednisolone, following clinical improvement, sudden high fever and worsening abdominal symptoms occurred. Symptomatic resolution occurred following ganciclovir administration, with CMV infection confirmed by colonic histopathology and metagenomic next-generation sequencing (mNGS).

引用

页数：4

共 15 条

[1] Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review [J].

Abrams, Joseph Y. ;

Godfred-Cato, Shana E. ;

Oster, Matthew E. ;

Chow, Eric J. ;

Koumans, Emilia H. ;

Bryant, Bobbi ;

Leung, Jessica W. ;

Belay, Ermias D. .

JOURNAL OF PEDIATRICS, 2020, 226 :45-+

[2]

[Anonymous], 2020, Naming the coronavirus disease (COVID-19) and the virus that causes it

[3] Cytomegalovirus [J].

Dioverti, M. Veronica ;

Razonable, Raymund R. .

MICROBIOLOGY SPECTRUM, 2016, 4 (04)

[4] A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology [J].

Fakhreddine, Ali Y. ;

Frenette, Catherine T. ;

Konijeti, Gauree G. .

GASTROENTEROLOGY RESEARCH AND PRACTICE, 2019, 2019

[5] Multisystem Inflammatory Syndrome in US Children and Adolescents [J].

Feldstein, Leora R. ;

Rose, Erica B. ;

Horwitz, Steven M. ;

Collins, Jennifer P. ;

Newhams, Margaret M. ;

Son, Mary Beth F. ;

Newburger, Jane W. ;

Kleinman, Lawrence C. ;

Heidemann, Sabrina M. ;

Martin, Amarilis A. ;

Singh, Aalok R. ;

Li, Simon ;

Tarquinio, Keiko M. ;

Jaggi, Preeti ;

Oster, Matthew E. ;

Zackai, Sheemon P. ;

Gillen, Jennifer ;

Ratner, Adam J. ;

Walsh, Rowan F. ;

Fitzgerald, Julie C. ;

Keenaghan, Michael A. ;

Alharash, Hussam ;

Doymaz, Sule ;

Clouser, Katharine N. ;

Giuliano, John S. ;

Gupta, Anjali ;

Parker, Robert M. ;

Maddux, Aline B. ;

Havalad, Vinod ;

Ramsingh, Stacy ;

Bukulmez, Hulya ;

Bradford, Tamara T. ;

Smith, Lincoln S. ;

Tenforde, Mark W. ;

Carroll, Christopher L. ;

Riggs, Becky J. ;

Gertz, Shira J. ;

Daube, Ariel ;

Lansell, Amanda ;

Coronado Munoz, Alvaro ;

Hobbs, Charlotte V. ;

Marohn, Kimberly L. ;

Halasa, Natasha B. ;

Patel, Manish M. ;

Randolph, Adrienne G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :334-346

[6] Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection [J].

Gaspar, Zsofia ;

Szabo, Balint Gergely ;

Cegledi, Andrea ;

Lakatos, Botond .

GEROSCIENCE, 2024, :167-187

[7] A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process [J].

Harwood, Rachel ;

Allin, Benjamin ;

Jones, Christine E. ;

Whittaker, Elizabeth ;

Ramnarayan, Padmanabhan ;

Ramanan, Athimalaipet, V ;

Kaleem, Musa ;

Tulloh, Robert ;

Peters, Mark J. ;

Almond, Sarah ;

Davis, Peter J. ;

Levin, Michael ;

Tometzki, Andrew ;

Faust, Saul N. ;

Knight, Marian ;

Kenny, Simon .

LANCET CHILD & ADOLESCENT HEALTH, 2021, 5 (02) :133-141

[8] Lower risk of multi-system inflammatory syndrome in children (MIS-C) with the omicron variant [J].

Lopez, Laura ;

Burgner, David ;

Glover, Catherine ;

Carr, Jeremy ;

Clark, Julia ;

Boast, Alison ;

Vasilunas, Nan ;

McMullan, Brendan ;

Francis, Joshua R. ;

Bowen, Asha C. ;

Blyth, Christopher C. ;

Macartney, Kristine ;

Crawford, Nigel W. ;

Carey, Emma ;

Wood, Nicholas ;

Britton, Philip N. .

LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2022, 27 :1-3

[9]

Mofenson Lynne M., 2009, Morbidity and Mortality Weekly Report, V58, P1

[10] Epidemiology and Severity of Illness of MIS-C and Kawasaki Disease During the COVID-19 Pandemic [J].

Molloy, Matthew J. ;

Auger, Katherine A. ;

Hall, Matt ;

Shah, Samir S. ;

Schondelmeyer, Amanda C. ;

Parikh, Kavita ;

Kazmier, Katherine M. ;

Katragadda, Harita ;

Jacob, Seethal A. ;

Jerardi, Karen E. ;

Ivancie, Rebecca ;

Hartley, David ;

Bryan, Mersine A. ;

Bhumbra, Samina ;

Arnold, Staci D. ;

Brady, Patrick W. .

PEDIATRICS, 2023, 152 (05)

← 1 2 →