Herein, we have reported the preparation, characterization, and acetone sensing properties of ZnO, 2%,5%, and 10% Na-doped ZnO samples synthesized using the microwave-assisted combustion method, aimed to enhance the sensitivity at low temperatures. The prepared samples were characterized using several characterization techniques to analyze their phase structure, crystallinity, and morphology. X-ray diffraction (XRD) analysis confirmed that the synthesized ZnO samples possess a well-crystalline hexagonal wurtzite crystal structure. The detailed experiments revealed that at an optimized temperature, i.e., similar to 50 degrees C, 5% Na-ZnO sample exhibited a significant sensitivity towards acetone concentrations of 100, 200, 300, 400, and 500 ppm with response value of similar to 39, similar to 54, similar to 100, similar to 214, and similar to 300% and the response and recovery time of similar to 442 /similar to 62 s, respectively. The results indicate that 5% Na-ZnO samples have a high sensing response towards acetone at low operating temperatures.