Ductal carcinoma in situ - The influence of the radiotherapy boost on local control

被引：41

作者：

Wong, Philip ^{[1
]}

Lambert, Christine ^{[1
]}

Agnihotram, Ramanakumar V. ^{[2
]}

David, Marc ^{[1
]}

Duclos, Marie ^{[1
]}

Freeman, Carolyn R. ^{[1
]}

机构：

[1] Division of Radiation Oncology, McGill University Health Centre, Montreal, QC, Canada

[2] Division of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada

来源：

International Journal of Radiation Oncology Biology Physics | 2012年 / 82卷 / 02期

关键词：

Regression analysis - Irradiation - Surgery - Risk assessment;

D O I：

10.1016/j.ijrobp.2011.03.045

中图分类号：

学科分类号：

摘要：

Purpose: Local recurrence (LR) of ductal carcinoma in situ (DCIS) is reduced by whole-breast irradiation after breast-conserving surgery (BCS). However, the benefit of adding a radiotherapy boost to the surgical cavity for DCIS is unclear. We sought to determine the impact of the boost on LR in patients with DCIS treated at the McGill University Health Centre. Methods and Materials: A total of 220 consecutive cases of DCIS treated with BCS and radiotherapy between January 2000 and December 2006 were reviewed. Of the patients, 36% received a radiotherapy boost to the surgical cavity. Median follow-up was 46 months for the boost and no-boost groups. Kaplan-Meier survival analyses and Cox regression analyses were performed. Results: Compared with the no-boost group, patients in the boost group more frequently had positive and

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