Cause of death for patients who present with primary progressive apraxia of speech

被引：0

作者：

Utianski, Rene L. ^{[1
]}

Meade, Gabriela ^{[1
]}

Duffy, Joseph R. ^{[1
]}

Boland, Sarah ^{[1
]}

Whitwell, Jennifer L. ^{[2
]}

Botha, Hugo ^{[1
]}

Josephs, Keith A. ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

来源：

PARKINSONISM & RELATED DISORDERS | 2025年 / 138卷

关键词：

Apraxia of speech; Cause of death; Mortality; Neurodegeneration; RICHARDSON-OLSZEWSKI SYNDROME; NATURAL-HISTORY; SURVIVAL;

D O I：

10.1016/j.parkreldis.2025.107968

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Apraxia of speech (AOS) can be the initial and sole manifestation of neurodegenerative diseases, termed primary progressive apraxia of speech (PPAOS). These patients frequently evolve to atypical parkinsonism. There is little information to inform end of life planning and expectations. Objective: This study explored causes of death in patients who presented with PPAOS. Methods: Data for 29 deceased PPAOS patients and for whom cause of death data were available were reviewed. Results: Median age at death was 76.25 years following a median disease duration of 9.78 years. Fifteen patients (52 %) succumbed to deterioration from the disease, ten (34 %) died from complications associated with dysphagia, and the remainder from a brain bleed associated with a fall (10 %) or medical aid in dying (3 %). Conclusions: The findings inform counseling and underscore the need for comprehensive, interdisciplinary care addressing swallowing impairments and systemic disease to prevent or delay causes of death.

引用

页数：3

共 18 条

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