Cellular and Humoral Immune Profiles After Hepatitis E Vaccination and Infection

被引：0

作者：

Overbo, Joakim ^{[1
]}

Dembinski, Jennifer L. ^{[1
]}

Nilsen, Toril Ranneberg ^{[2
]}

Sriranganathan, Vethanayaki ^{[3
]}

Dimova-Svetoslavova, Veselka Petrova ^{[3
]}

Aziz, Asma ^{[2
,4
,5
]}

Zaman, K. ^{[4
]}

Julin, Cathinka Halle ^{[1
]}

Qadri, Firdausi ^{[4
]}

Stene-Johansen, Kathrine ^{[1
]}

Bhuiyan, Taufiqur Rahman ^{[4
]}

Haque, Warda ^{[4
]}

Dudman, Susanne ^{[2
,3
]}

机构：

[1] Norwegian Inst Publ Hlth, NO-0213 Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Dept Microbiol, NO-0424 Oslo, Norway

[3] Oslo Univ Hosp, NO-0424 Oslo, Norway

[4] Int Ctr Diarrheal Dis Res ICDDR B, Dhaka 1212, Bangladesh

[5] Int Vaccine Inst, Seoul 08826, South Korea

来源：

VIRUSES-BASEL | 2025年 / 17卷 / 07期

关键词：

hepatitis E virus; HEV; vaccine; immunology; IgG; T-cell; E VIRUS; T-CELL; PROTEINS;

D O I：

10.3390/v17070901

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) causes significant morbidity and mortality globally, particularly affecting vulnerable populations such as pregnant women. HEV239 (Hecolin (R)), a recombinant vaccine containing the immunodominant protruding (E2) domain of the HEV capsid protein, has demonstrated effectiveness, yet detailed human cellular immune responses remain understudied. This study characterized humoral and cellular immune responses following vaccination with HEV239 or natural HEV infection in healthy Bangladeshi women aged 16-39 years. Using dual IFN gamma and IL-4 ELISpot assays, we found robust, predominantly Th1-mediated cellular responses at 30 days after the third vaccine dose, comparable to responses during acute infection. Longitudinal antibody assessments confirmed sustained antibody production, primarily against the E2 domain of genotypes 1 and 3, persisting up to two years post-vaccination. Despite limitations related to sample size and assay sensitivity, our findings underscore the immunogenic potential of HEV239 and support a broader use in HEV-endemic regions.

引用

页数：12

共 29 条

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