Natural Products in Regulating Mitophagy for the Intervention of Atherosclerosis and Its Risk Factors: Mechanisms and Therapeutic Potential

被引：0

作者：

Li, Yu-Han ^{[1
]}

Ma, Hao ^{[2
]}

Wang, Ying-Rui ^{[1
]}

Zhang, Si-Xiang ^{[1
]}

Zhao, You-Min ^{[1
]}

Liu, Zheng ^{[3
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Jinan, Peoples R China

[2] Taizhou Hosp Tradit Chinese Med, Taizhou, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Dept Peripheral Vasc Dis, Affiliated Hosp, Jinan, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2025年

关键词：

atherosclerosis; mitophagy; natural products; risk factors; treatment; INDUCED MITOCHONDRIAL DYSFUNCTION; IN-VITRO; OXIDATIVE STRESS; DIABETIC-NEPHROPATHY; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; ARTERIAL STIFFNESS; CHLOROGENIC ACID; ASTRAGALOSIDE IV; BLOOD-PRESSURE;

D O I：

10.1002/ptr.70041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Atherosclerosis (AS) is a chronic systemic disease that poses a significant and escalating global challenge. The pathological process of AS involves multiple aspects. In addition to lipid-lowering therapy, therapeutic strategies such as anti-inflammatory and immunotherapy have been proposed, and attention has been paid to the intervention of its risk factors. However, the available drugs are still limited. Therefore, there is an urgent need to discover new pharmacological targets and drugs. Mitophagy is closely associated with AS and its risk factors, and it represents an important breakthrough in the intervention of AS and its risk factors. Natural products (NPs), with multiple pharmacological activities and lower toxicity, have caught attention as the new force in the treatment of AS and its risk factors. This review discusses the mechanisms and therapeutic potential of NPs in regulating mitophagy to alleviate AS and intervene in its risk factors. It also introduces the application prospects of the NPs, with the expectation of contributing to the treatment of AS and the development of innovative drugs.

引用

页数：32

共 295 条

[11] Research progress on pharmacological effects and new dosage forms of baicalin [J].

Bao, Minglong ;

Ma, Yunfei ;

Liang, Mei ;

Sun, Xinyi ;

Ju, Xianghong ;

Yong, Yanhong ;

Liu, Xiaoxi .

VETERINARY MEDICINE AND SCIENCE, 2022, 8 (06) :2773-2784

[12] Ferulic acid and its therapeutic potential as a hormetin for age-related diseases [J].

Barone, Eugenio ;

Calabrese, Vittorio ;

Mancuso, Cesare .

BIOGERONTOLOGY, 2009, 10 (02) :97-108

[13] In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids [J].

Basheer, Loai ;

Schultz, Keren ;

Guttman, Yelena ;

Kerem, Zohar .

FOOD CHEMISTRY, 2017, 237 :895-903

[14] Risk Assessment of Chlorogenic and Isochlorogenic Acids in Coffee By-Products [J].

Behne, Sascha ;

Franke, Heike ;

Schwarz, Steffen ;

Lachenmeier, Dirk W. .

MOLECULES, 2023, 28 (14)

[15] The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine [J].

Bekebrede, Anna F. ;

Keijer, Jaap ;

Gerrits, Walter J. J. ;

de Boer, Vincent C. J. .

NUTRIENTS, 2020, 12 (01)

[16] Ambient Air Pollution and Atherosclerosis: Recent Updates [J].

Bevan, Graham H. ;

Al-Kindi, Sadeer G. ;

Brook, Robert ;

Rajagopalan, Sanjay .

CURRENT ATHEROSCLEROSIS REPORTS, 2021, 23 (10)

[17] Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects With Prediabetes and Type 2 Diabetes Mellitus [J].

Bhansali, Shipra ;

Bhansali, Anil ;

Walia, Rama ;

Saikia, Uma Nahar ;

Dhawan, Veena .

FRONTIERS IN ENDOCRINOLOGY, 2017, 8

[18] Anti-inflammatory and immunoregulatory effects of icariin and icaritin [J].

Bi, Zhangyang ;

Zhang, Wei ;

Yan, Xiaoyan .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 151

[19] Drug delivery breakthrough technologies-A perspective on clinical and societal impact [J].

Bittner, Beate ;

Sanchez-Felix, Manuel ;

Lee, Dennis ;

Koynov, Athanas ;

Horvath, Joshua ;

Schumacher, Felix ;

Matoori, Simon .

JOURNAL OF CONTROLLED RELEASE, 2023, 360 :335-343

[20] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel [J].

Boren, Jan ;

Chapman, M. John ;

Krauss, Ronald M. ;

Packard, Chris J. ;

Bentzon, Jacob F. ;

Binder, Christoph J. ;

Daemen, Mat J. ;

Demer, Linda L. ;

Hegele, Robert A. ;

Nicholls, Stephen J. ;

Nordestgaard, Brge G. ;

Watts, Gerald F. ;

Bruckert, Eric ;

Fazio, Sergio ;

Ference, Brian A. ;

Graham, Ian ;

Horton, Jay D. ;

Landmesser, Ulf ;

Laufs, Ulrich ;

Masana, Luis ;

Pasterkamp, Gerard ;

Raal, Frederick J. ;

Ray, Kausik K. ;

Schunkert, Heribert ;

Taskinen, Marja-Riitta ;

van de Sluis, Bart ;

Wiklund, Olov ;

Tokgozoglu, Lale ;

Catapano, Alberico L. ;

Ginsberg, Henry N. .

EUROPEAN HEART JOURNAL, 2020, 41 (24) :2313-+

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