Controlled release for drug of complex-shell block copolymer micelles

被引：0

作者：

Zhang, Xiaohui ^{[1
]}

Zhao, Shuyi ^{[1
]}

Ma, Jinghong ^{[1
]}

Yang, Shuguang ^{[1
]}

Gong, Jinghua ^{[1
]}

机构：

[1] State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, China

来源：

Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2012年 / 28卷 / 08期

关键词：

Block copolymers - Controlled drug delivery - Atom transfer radical polymerization - Shells (structures) - Targeted drug delivery - Ultraviolet spectroscopy - Acrylic monomers - Transmission electron microscopy - Dynamic light scattering;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Poly(t-butyl acrylate)-b-poly(2-dimethylamino) ethyl methacrylate (PtBA-b-PDMAEMA) and poly(t-butyl acrylate)-b-poly(n-isopropyl acrylamide) (PtBA-b-PNIPAM) were synthesized by sequential atom transfer radical polymrization (ATRP). Then micelles with complex-shell structure were formed in selective solvent by self-assemble. The hydrodynamic radius (Rh) and size-distribution of the micelles were studied in detail via dynamic light scattering (DLS) and transmission electron microscope (TEM). The controlled release of drug from the complex-shell micelles was characterized by ultraviolet spectrum (UV). The results indicate that the controllable drug channels could be formed in the shell of the micelles, which realize the accurate control of the drug release.

引用

页码：125 / 128