Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review

被引：0
作者：
Su, Wenya [1 ]
Wang, Wenjia [1 ]
Li, Ling [1 ]
Zhang, Mengge [1 ]
Xu, Hai [1 ]
Fu, Chengzhang [2 ,3 ]
Pang, Xiuhua [1 ]
Wang, Mingyu [1 ]
机构：
[1] Shandong Univ, Microbial Technol Inst, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China
[2] Saarland Univ, Helmholtz Inst Pharmaceut Res Saarland HIPS, Helmholtz Ctr Infect Res HZI, D-66123 Saarbrucken, Germany
[3] Saarland Univ, Dept Pharm, D-66123 Saarbrucken, Germany
来源：
ENGINEERING MICROBIOLOGY | 2024年 / 4卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Gram-negative bacteria; Tigecycline; Tigecycline resistance; Resistance mechanisms; RND efflux pump; MULTIPLE-ANTIBIOTIC-RESISTANCE; MULTIDRUG EFFLUX PUMP; RIBOSOMAL S10 PROTEIN; ACINETOBACTER-BAUMANNII; ESCHERICHIA-COLI; KLEBSIELLA-PNEUMONIAE; DECREASED SUSCEPTIBILITY; PSEUDOMONAS-AERUGINOSA; GENETIC-CHARACTERIZATION; REDUCED SUSCEPTIBILITY;
D O I：
10.1016/j.engmic.2024.100165
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Tigecycline serves as a critical "final-resort " antibiotic for treating bacterial infections caused by multidrugresistant bacteria for which treatment options are severely limited. The increasing prevalence of tigecycline resistance, particularly among Gram-negative bacteria, is a major concern. Various mechanisms have been identified as contributors to tigecycline resistance, including upregulation of nonspecific Resistance Nodulation Division (RND) efflux pumps due to mutations in transcriptional regulators, enzymatic modification of tigecycline by monooxygenase enzymes, and mutations affecting tigecycline binding sites. This review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.
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页数：8
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