To address industrial challenges in thermal efficiency equipment, current research emphasizes optimizing system designs and employing efficient heat transfer fluids. In this paper, the turbulent heat transfer performance of nanofluids in a TG-type vortex generator is investigated by numerical simulations using the mixture model at Re = 2,600-17,000 operating conditions. Gap-Diameter ratio (G/D) are investigated in order to select a vortex generator structure with the optimal performance (Best performance when G/D = 1.2). Then the impact of nanofluid type, concentration, and CNT diameter on heat transfer was quantified. It was found that the Nusselt number of Vortex generators was by 1.75-2.44 times higher than that of the empty tube. The nanofluids Al2O3-H2O, SiC-H2O and CNT-H2O achieved Nu(avg) increases of 1.04-1.17, 1.30-1.46 and 5.36-5.98 times over water, respectively. By increasing the Fc and suppressing the S-T, CNT can reduce total irreversible losses while achieving efficient heat transfer. In addition, the comprehensive heat transfer performance of single-walled carbon nanotubes (SWCNT) is better than that of multi-walled carbon nanotubes (MWCNT). MWCNT = 50 nm, MWCNT < 10 nm and SWCNT exhibited PEC enhancements of 4.03-5.07, 4.48-5.70, and 6.92-9.07 times over water, respectively. This study provides valuable insight into the optimization of heat exchangers and other industrial thermal systems.