The Role of PI3K/AKT/mTOR Signaling in Tumor Radioresistance and Advances in Inhibitor Research

被引：0

作者：

Zhan, Jian ^{[1
]}

Juecker, Manfred ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Biochem & Signal Transduct, Martinistr 52, D-20246 Hamburg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 14期

关键词：

PI3K; AKT; mTOR; radioresistance; PHOSPHOINOSITIDE 3-KINASE BETA; NEWLY-DIAGNOSED GLIOBLASTOMA; NEGATIVE BREAST-CANCER; PHASE-I; ENHANCES RADIOSENSITIVITY; MTOR INHIBITOR; DNA-DAMAGE; PROMOTING AUTOPHAGY; RADIATION-THERAPY; CERVICAL-CANCER;

D O I：

10.3390/ijms26146853

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a major threat to human health, and radiotherapy is a key treatment method. However, its effectiveness is often limited by tumor radioresistance. The PI3K/AKT/mTOR signaling pathway is commonly dysregulated in cancers and plays a significant role in radioresistance, though its exact mechanisms remain unclear. This review discusses how this pathway regulates tumor radioresistance and highlights recent progress in the development of related inhibitors in preclinical and clinical studies. These findings aim to guide clinical treatment strategies and provide new approaches to overcoming radioresistance.

引用

页数：29

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