Bulk RNA sequencing combined with single-cell RNA sequencing analysis revealed the ferroptosis immune target of osteoarthritis synovial fibroblasts

被引:0
作者
Wu, Qian [1 ]
Zhou, Liang [2 ]
Xue, Yuan [3 ]
Wang, Jiaqian [4 ]
机构
[1] Soochow Univ, Affiliated Hosp 1, Suzhou Med Coll, Dept Orthoped Surg, Suzhou 215006, Jiangsu, Peoples R China
[2] Yangzhou Univ, Huaian Hosp, Peoples Hosp Huaian 5, Dept Orthoped, Huaian 223399, Jiangsu, Peoples R China
[3] Soochow Univ, Wuxi Peoples Hosp 9, Dept Orthoped, Wuxi 214026, Jiangsu, Peoples R China
[4] Fudan Univ, Dept Orthopaed Surg, Zhongshan Hosp, Shanghai 200032, Peoples R China
关键词
D O I
10.1016/j.gendis.2025.101587
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:3
相关论文
共 5 条
[1]   Interleukin-17A Causes Osteoarthritis-Like Transcriptional Changes in Human Osteoarthritis-Derived Chondrocytes and Synovial Fibroblasts In Vitro [J].
Mimpen, Jolet Y. ;
Baldwin, Mathew J. ;
Cribbs, Adam P. ;
Philpott, Martin ;
Carr, Andrew J. ;
Dakin, Stephanie G. ;
Snelling, Sarah J. B. .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[2]   TNF inhibition enhances depletion of synovial fibroblasts by ferroptosis [J].
Phillips, Robert .
NATURE REVIEWS RHEUMATOLOGY, 2022, 18 (04) :186-186
[3]   The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis [J].
Sellam, Jeremie ;
Berenbaum, Francis .
NATURE REVIEWS RHEUMATOLOGY, 2010, 6 (11) :625-635
[4]   TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models [J].
Wu, Jiao ;
Feng, Zhuan ;
Chen, Liang ;
Li, Yong ;
Bian, Huijie ;
Geng, Jiejie ;
Zheng, Zhao-Hui ;
Fu, Xianghui ;
Pei, Zhuo ;
Qin, Yifei ;
Yang, Liu ;
Zhao, Yilin ;
Wang, Ke ;
Chen, Ruo ;
He, Qian ;
Nan, Gang ;
Jiang, Xuejun ;
Chen, Zhi-Nan ;
Zhu, Ping .
NATURE COMMUNICATIONS, 2022, 13 (01)
[5]   Glutamine exerts a protective effect on osteoarthritis development by inhibiting the Jun N-terminal kinase and nuclear factor kappa-B signaling pathways [J].
Zhong, Lin ;
Cao, Le ;
Song, Rui ;
Yang, Xue-Fei ;
Li, Jia-Le ;
Yang, Hai-Tao ;
Zhou, Hong-Xiang ;
Fan, Hai-Tao .
SCIENTIFIC REPORTS, 2022, 12 (01)