Total-body 18F-FDG PET/CT: more choices to promote clinical scanning efficiency

被引：0

作者：

Xiao, Jie ^{[1
,2
,3
]}

Chen, Shuguang ^{[1
,2
,3
]}

Hou, Xiaoguang ^{[1
,2
,3
]}

Yu, Haojun ^{[1
,2
,3
]}

Liu, Siwei ^{[1
,2
,3
]}

Gu, Taoying ^{[1
,2
,3
]}

Liu, Guobing ^{[1
,2
,3
]}

Ge, Qi ^{[4
]}

Wang, Jingyi ^{[4
]}

Shi, Hongcheng ^{[1
,2
,3
]}

机构：

[1] Zhongshan Hosp, Dept Nucl Med, 180 Fenglin Rd, Shanghai, Peoples R China

[2] Fudan Univ, Inst Nucl Med, Shanghai, Peoples R China

[3] Shanghai Inst Med Imaging, Shanghai, Peoples R China

[4] United Imaging Healthcare Co Ltd, Cent Res Inst, Shanghai, Peoples R China

来源：

EJNMMI RESEARCH | 2025年 / 15卷 / 01期

关键词：

Total-body PET/CT; Scan strategy; Scanning efficiency; F-18-FDG; Throughput; GUIDELINE;

D O I：

10.1186/s13550-025-01290-y

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background The study aims to maximize clinical scan efficiency for Total-body (TB) F-18-FDG PET/CT systems by optimizing scan strategies based on theoretical models and clinical experience from a single center. Results This prospective study include two parts. The first part involved simulation experiments using theoretical models to maximize patient throughput and/or minimizing radiotracer activity across four clinical scanning scenarios: fixed working time, predetermined radiotracer activity, integration of various injection activity regimens for a fixed number of patients, and incorporation of dynamic scans into routine static scans within a fixed working time. The optimal scan strategies for these scenarios were then proposed. The second part validated the estimated throughput results through high-throughput tests performed in the real clinical settings with an fixed working time of 8 h. Under a fixed working time of 8 h, the theoretical patient throughput for full-activity, half-activity, 1/3-activity, and 1/10-activity injection regimens was 60, 48, 43, 30 patients, respectively. The corresponding real clinical throughput achieved was 60, 49, 48, 28 patients. For a total F-18-FDG activity of 37,000 to 148,000 MBq (1 to 4 Ci), the 1/3-activity injection regimen yielded the highest patient throughput, ranging 52 to 72 patients. Strategically combining various injection activity regimens could reduce radiotracer activity consumption. Additionally, placing full-activity dynamic scans after routine static scans for full-activity, half-activity, and 1/3-activity, and before 1/10 activity, proved to ba more economical strategies. Conclusions Optimized scan strategies for typical clinical scenarios of TB F-18-FDG PET/CT systems were proposed, which could promote clinical scan efficiency and accommodate diverse clinical requirements. These strategies enable centers to balance throughput and activity efficiency while maintaining diagnostic quality.

引用

页数：12