Association of accelerometer-measured physical activity with adverse cardiovascular outcomes in individuals with or without chronic kidney diseases: the UK biobank study

被引：0

作者：

Ko, Byounghwi ^{[1
]}

Ko, Ye Eun ^{[1
]}

Jung, Chan-Young ^{[2
]}

Kang, Dong Hoon ^{[3
]}

Park, Cheol Ho ^{[1
]}

Koh, Hee Byung ^{[1
]}

Heo, Ga Young ^{[4
]}

Kim, Hyung Woo ^{[1
]}

Park, Jung Tak ^{[1
]}

Yoo, Tae-Hyun ^{[1
]}

Kang, Shin-Wook ^{[1
]}

Park, Sue Kyung ^{[5
]}

Kim, Soo Wan ^{[6
]}

Kim, Yeong Hoon ^{[7
]}

Sung, Suah ^{[8
]}

Oh, Kook Hwan ^{[9
]}

Han, Seung Hyeok ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Inst Kidney Dis Res, Dept Internal Med, Yonsei Ro 50, Seoul, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Div Nephrol,Dept Internal Med, Seoul, South Korea

[3] Ilsan Hosp, Natl Hlth Insurance Serv Med Ctr, Dept Internal Med, Goyangshi, Gyeonggi Do, South Korea

[4] Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea

[6] Chonnam Natl Univ, Sch Med, Div Nephrol, Gwangju, South Korea

[7] Inje Univ, Busan Paik Hosp, Internal Med, Div Nephrol, Pusan, South Korea

[8] Eulji Univ, Nowon Eulji Med Ctr, Dept Internal Med, Seoul, South Korea

[9] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea

来源：

JOURNAL OF NEPHROLOGY | 2025年

关键词：

Movement behavior; Physical activity; Chronic kidney disease; Cardiovascular disease; Stroke; All-cause mortality; EPIDEMIOLOGY; RISK; INACTIVITY; EXERCISE;

D O I：

10.1007/s40620-025-02345-y

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background Physical activity is important for health and longevity, but little is known on patients living with chronic kidney disease (CKD). In fact, most studies in patients with CKD have relied on self-reported data, highlighting an unmet need for studies using objective measurements. We investigated the association between device-measured physical activity and adverse outcomes by CKD status. Methods This study included 65,088 participants without CKD and 1170 with CKD, from the UK Biobank, who completed a one-week accelerometer assessment. CKD was defined as either baseline estimated glomerualr filtration rate (eGFR) < 60 mL/min/1.73 m(2) or two consecutive eGFR measurements < 60 mL/min/1.73 m(2) from primary care data recorded prior to the accelerometer study. The main predictor was device-measured physical activity, categorized into quartiles. The primary outcome was all-cause mortality; secondary outcomes included three-point major adverse cardiovascular events and non-cardiovascular death. We used cause-specific competing risk models adjusting for multiple covariates. Results Over a median follow-up period of 8.04 years, all-cause mortality occurred in 2028 (3.06%) participants, with an incidence of 3.84/1000 person-years. Compared with the 1st quartile, the adjusted hazard ratios (95% confidence intervals) for all-cause mortality for the 2nd, 3rd, and 4th quartiles were 0.72 (0.64-0.80), 0.65 (0.57-0.72), and 0.57 (0.49-0.66) in non-CKD, and 0.56 (0.33-0.96), 0.42 (0.23-0.79), and 0.33 (0.16-0.68) in CKD participants. This pattern was consistent for non-cardiovascular deaths. However, device-measured physical activity was not significantly associated with three-point major adverse cardiovascular events in CKD, while a significant association was observed in the non-CKD group. Conclusion Device-measured physical activity showed differential associations with outcomes by CKD status. The null association between physical activity and three-point major adverse cardiovascular events in CKD suggests a complex cardiovascular pathophysiology in this population. [GRAPHICS] .

引用

页数：13