Electrochemical Ni-Catalyzed α-Selective Hydrocarboxylation of Styrenes with CO2

被引：0

作者：

Qi, Weikang ^{[1
,2
]}

Wang, Yanwei ^{[1
,2
]}

Qiu, Youai ^{[1
,2
,3
]}

机构：

[1] Nankai Univ, Coll Chem, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elemento Organ Chem, Frontiers Sci Ctr New Organ Matter, Coll Chem,Haihe Lab Sustainable Chem Transformat, Tianjin 300071, Peoples R China

[3] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China

来源：

ORGANIC LETTERS | 2025年

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CARBON-DIOXIDE; REGIOSELECTIVE HYDROCARBOXYLATION; CARBOXYLATION; ALKENES; DICARBOXYLATION; OLEFINS; COBALT; IRON;

D O I：

10.1021/acs.orglett.5c02243

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, an alpha-selective electrocarboxylation of styrene enabled by Ni-H utilizing water as the hydride source under a CO2 atmosphere is described. This approach features high regioselectivity and good functional-group compatibility. A series of anti-inflammatory drug molecules (ibuprofen, naproxen, flurbiprofen, and fenoprofen) were obtained in a direct and rapid way. Moreover, mechanistic studies have been conducted and provide support for the proposed mechanism.

引用

页数：6

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