Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

被引：0

作者：

Onyeabo, Chimaraoke ^{[1
]}

Achi, Ngozi K. ^{[1
]}

Ekeleme-Egedigwe, Chima A. ^{[2
]}

Ebere, Chidinma U. ^{[1
]}

Okoro, Chidinma K. ^{[1
]}

机构：

[1] Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia State, Nigeria

[2] Department of Chemistry/Biochemistry, Federal University Ndufu-Alike Ikwo, PMB 1010 Abakaliki, Ebonyi State, Nigeria

来源：

Acta Scientiarum Polonorum, Technologia Alimentaria | 2017年 / 16卷 / 02期

关键词：

Blood - Plant extracts - Cholesterol;

D O I：

10.17306/J.AFS.0492

中图分类号：

学科分类号：

摘要：

Background. Justicia carnea is a medicinal plant used widely in Nigeria which is reported to have diverse functions, including blood-boosting potential. Aim. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. Methods. The experimental animals were randomly grouped into five groups of six rats each - group 1 (non- -anemic control), group 2 (anemic control), group 3 (500 mg/kg of JC extract), group 4 (1000 mg/kg of JC extract) and group 5 (DMSO control). Phenylhydrazine was administered once at a dose of 80 mg/kg b.w. to induce hemolytic anemia. After 28 days of extract administration, they were humanely sacrificed and the serum collected was used for biochemical analysis. Results. In the acute toxicity study, the LD50 was found to be above 5000 mg/kg body weight. Packed Cell Volume (PCV) values, Red Blood cell (RBC) and haemoglobin (Hb) concentrations decreased (p © Wydawnictwo Uniwersytetu Przyrodniczego w Poznaniu.

引用

页码：217 / 230