Antimicrobial activity of silver nanoparticles synthesized using honey and gamma radiation against silver-resistant bacteria from wounds and burns

被引：14

作者：

Hosny, A.M.S. ^{[1
]}

Kashef, M.T. ^{[1
]}

Rasmy, S.A. ^{[1
]}

Aboul-Magd, D.S. ^{[2
]}

El-Bazza, Z.E. ^{[2
]}

机构：

[1] Microbiology and Immunology Department, Faculty of Pharmacy, Cairo University, Cairo,11562, Egypt

[2] Drug Radiation Research Department, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo,11787, Egypt

来源：

Advances in Natural Sciences: Nanoscience and Nanotechnology | 2017年 / 8卷 / 04期

关键词：

Bacteria - Irradiation - Food products - Metal nanoparticles - Particle size - Synthesis (chemical) - Antimicrobial agents - Fourier transform infrared spectroscopy - Ultraviolet visible spectroscopy - Gamma rays - Microwave integrated circuits;

D O I：

10.1088/2043-6254/aa8b44

中图分类号：

学科分类号：

摘要：

Silver nanoparticles (AgNPs) are promising antimicrobial agents for treatment of wounds and burns. We synthesized AgNPs using honey at different pH values or with different gamma irradiation doses. The resulting nanoparticles were characterized by UV-vis spectroscopy, TEM, DLS and FTIR. Their antimicrobial activity, against standard bacterial strains and silver-resistant clinical isolates from infected wounds and burns, was evaluated in vitro through determination of their minimum inhibitory concentration (MIC). AgNPs prepared using 30 g of honey exposed to 5 kGy gamma radiation had the best physical characters regarding stability and uniformity of particle size and shape. They recorded the lowest MIC values against both the standard and silver-resistant isolates. In conclusion, honey and gamma radiation can be used in synthesis of highly stable pure AgNPs, without affecting the physico-chemical and antimicrobial activity of honey. This offered an advantage in terms of inhibition of silver-resistant bacteria isolates. © 2017 Vietnam Academy of Science & Technology.

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