In order to reveal the influent of δ phase on the hot deformation behavior of GH4169 alloy, various δ phase sizes and distribution, obtained by the different heat treatment, were investigated. Then, those different samples were hot deformed at 980°C using Gleeble-1500 hot compression testing machine. The effect of pre-precipitated δ phase on hot deformation mechanism and microstructure after deformation of GH4169 alloy was systematically studied. The results show that the amount and distribution of δ phase significantly affect microstructure evolution and recrystallization behavior during hot deformation. The amount of δ phase increases, the stress of deformation reduce. Besides, δ phase promotes the nucleation and growth of recrystallization grains, especially δ precipitation in grain boundary. Furthermore, hot deformation accelerates the dissolution of pre-precipitated δ phase during deformation at 980°C.