INSIDE in-beam positron emission tomography system for particle range monitoring in hadrontherapy

被引：63

作者：

Bisogni, Maria Giuseppina ^{[1
,2
]}

Attili, Andrea ^{[3
,4
]}

Battistoni, Giuseppe ^{[5
]}

Belcari, Nicola ^{[1
,2
]}

Camarlinghi, Niccolo' ^{[1
,2
]}

Cerello, Piergiorgio ^{[4
]}

Coli, Silvia ^{[4
]}

Del Guerra, Alberto ^{[1
,2
]}

Ferrari, Alfredo ^{[6
]}

Ferrero, Veronica ^{[3
,4
]}

Fiorina, Elisa ^{[4
]}

Giraudo, Giuseppe ^{[4
]}

Kostara, Eleftheria ^{[2
]}

Morrocchi, Matteo ^{[1
,2
]}

Pennazio, Francesco ^{[4
]}

Peroni, Cristiana ^{[3
,4
]}

Piliero, Maria Antonietta ^{[1
,2
]}

Pirrone, Giovanni ^{[1
,2
]}

Rivetti, Angelo ^{[4
]}

Rolo, Manuel D. ^{[4
]}

Rosso, Valeria ^{[1
,2
]}

Sala, Paola ^{[5
]}

Sportelli, Giancarlo ^{[1
,2
]}

Wheadon, Richard ^{[4
]}

机构：

[1] University of Pisa, Department of Physics, Largo B. Pontecorvo 3, Pisa,56127, Italy

[2] Istituto Nazionale Fisica Nucleare INFN, Sezione di Pisa, Largo B. Pontecorvo 3, Pisa,56127, Italy

[3] University of Torino, Department of Physics, Via Pietro Giuria 1, Torino,10125, Italy

[4] Istituto Nazionale Fisica Nucleare INFN, Sezione di Torino, Via Pietro Giuria 1, Torino,10125, Italy

[5] Istituto Nazionale Fisica Nucleare INFN, Sezione di Milano, Via Celoria 16, Milano,20133, Italy

[6] Organisation Européenne pour la Recherche Nucléaire CERN, Geneva 23,CH-1211, Switzerland

来源：

Journal of Medical Imaging | 2017年 / 4卷 / 01期

关键词：

Electrons - Medical imaging - Positrons - Quality assurance - Scanning;

D O I：

10.1117/1.JMI.4.1.011005

中图分类号：

学科分类号：

摘要：

The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators of the treatment plan correctness. Among the available imaging techniques, positron emission tomography (PET) has long been investigated and then clinically applied to proton and carbon beams. In 2013, the Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal imaging concept that combines an in-beam PET scanner with a tracking system for charged particle imaging. This paper presents the general architecture of the INSIDE project but focuses on the in-beam PET scanner that has been designed to reconstruct the particles range with millimetric resolution within a fraction of the dose delivered in a treatment of head and neck tumors. The in-beam PET scanner has been recently installed at the Italian National Center of Oncologic Hadrontherapy (CNAO) in Pavia, Italy, and the commissioning phase has just started. The results of the first beam test with clinical proton beams on phantoms clearly show the capability of the in-beam PET to operate during the irradiation delivery and to reconstruct on-line the beam-induced activity map. The accuracy in the activity distal fall-off determination is millimetric for therapeutic doses. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).

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