Impact of COVID-19 on Hematologic Cancer Patients: Insights From the Late Pandemic Phase

被引：0

作者：

Caracciolo, Daniele ^{[1
,2
]}

D'Aquino, Giuseppe ^{[1
]}

Froio, Caterina ^{[1
]}

Romeo, Caterina ^{[1
]}

Bosco, Vincenzo ^{[3
]}

Pensabene, Giulia ^{[1
]}

Tedesco, Ludovica ^{[1
]}

Tagliaferri, Pierosandro ^{[1
,2
]}

Tassone, Pierfrancesco ^{[1
,2
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Campus Salvatore Venuta, Catanzaro, Italy

[2] AOU Renato Dulbecco, Med & Translat Oncol, Catanzaro, Italy

[3] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy

来源：

CANCER MEDICINE | 2025年 / 14卷 / 15期

关键词：

chronic lymphocytic leukemia; COVID-19; hematologic malignancies; late pandemic phase; multiple myeloma; myelodysplastic syndrome; non-Hodgkin lymphoma; MALIGNANCIES;

D O I：

10.1002/cam4.71112

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThe COVID-19 pandemic significantly increased mortality risks for individuals with hematological malignancies.Patients and MethodsWe conducted a single-center observational study, focusing on the late pandemic phase of the infection (2022-2023), to identify risk factors associated with COVID-19 outcomes in vaccinated patients with hematological malignancies.ResultsEighty-five COVID-19 cases were recorded among patients with hematological malignancies, primarily Multiple Myeloma (MM) (38.8%), chronic lymphocytic leukemia (CLL) (10.6%) and Non-Hodgkin Lymphoma (NHL) (35.3%). Despite a high COVID-19 vaccination rate (97.6%), severe/critical illness occurred in 23.5% of patients. The overall COVID-19-related mortality rate was 22.4%, with a 30-day mortality rate of 11.8%. Although mortality rates significantly decreased over the observation time (27.7% vs. 16.7%), this trend was not confirmed in critical infection carriers.ConclusionOur data confirm that, despite a reduction in critical infections and overall mortality rates over time, patients with hematological malignancies remain at high risk during the endemic phase of SARS-CoV-2 infection.

引用

页数：6

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