Outcomes of endoscopic submucosal dissection for treatment of superficial anal squamous cell carcinoma: Multicenter international experience

被引:0
作者
Fraile-Lopez, Miguel [1 ]
Pioche, Mathieu [2 ]
Rivory, Jerome [2 ]
Manolakis, Anastassios [3 ]
Takeuchi, Yoji [4 ,5 ]
Kuribayashi, Shiko [6 ]
Sato, Keigo [6 ]
de Tejada, Alberto Herreros [7 ]
Rosa, Diego de Frutos [7 ]
Kanesaka, Takashi [5 ]
Tanabe, Mayo [8 ]
Haji, Amyn [9 ]
Santos-Antunes, Joao [10 ,11 ]
Morais, Rui [10 ]
Tsiamoulos, Zacharias [12 ]
Uchima, Hugo [13 ,14 ]
Parra-Blanco, Adolfo [15 ]
Cagigal, Maria Luisa [16 ]
Teran, Alvaro [1 ]
de Santiago, Enrique Rodriguez [17 ]
机构
[1] Marques Valdecilla Univ Hosp, Valdecilla Res Inst IDIVAL, Gastroenterol & Hepatol Dept, Clin & Translat Res Digest Dis, Santander, Spain
[2] Hop Edouard Herriot, Gastroenterol & Endoscopy Unit, Lyon, France
[3] Gen Univ Hosp Larissa, Dept Gastroenterol, Larisa, Greece
[4] Gunma Univ Hosp, Endoscopy & Endoscop Surg, Meabashi, Japan
[5] Osaka Int Canc Inst, Dept Gastrointestinal Oncol, Osaka, Japan
[6] Gumma Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Tokyo, Japan
[7] Autonomous Univ Madrid, Puerta Hierro Univ Hosp, Res Inst Segovia Arana, Gastroenterol Dept, Majadahonda, Spain
[8] Showa Univ, Koto Toyosu Hosp, Digest Dis Ctr, Koto Ku, Tokyo, Japan
[9] Kings Coll Hosp NHS Fdn Trust, Colorectal Surg, London, England
[10] Ctr Hosp Sao Joao, Gastroenterol, EPE, Porto, Portugal
[11] IPATIMUP, Glycobiol & Canc, Porto, Portugal
[12] East Kent Hosp Univ NHS Fdn Trust, Queen Elizabeth Queen Mother Hosp, Dept Gastroenterol, Canterbury, England
[13] Hosp Univ Germans Trias i Pujol, Endoscopy Unit, Badalona, Spain
[14] Ctr Med Teknon, Endoscopy Unit, Barcelona, Spain
[15] Nottingham Univ Hosp NHS Trust, NIHR Nottingham Digest Dis Biomed Res Unit, Nottingham, England
[16] Marques Valdecilla Univ Hosp, Pathol Dept, Santander, Spain
[17] Univ Alcala, Hosp Univ Ramon & Cajal, Gastroenterol & Hepatol, IRYCIS, Madrid, Spain
关键词
Endoscopy Upper GI Tract; Diagnosis and imaging (inc chromoendoscopy; NBI; iSCAN; FICE; CLE); Endoscopic resection (ESD; EMRc; Endoscopy Lower GI Tract; Endoscopic resection (polypectomy; ESD; MAGNIFYING ENDOSCOPY; GUIDELINES;
D O I
10.1055/a-2641-5597
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and study aims Data on feasibility of endoscopic submucosal dissection (ESD) for treatment of superficial anal squamous cell carcinoma are limited. This study aimed to evaluate outcomes of ESD in this anatomical location. Patients and methods This was a multicenter retrospective study including patients who underwent ESD for treatment of superficial ASCC. Results Twenty-three patients with superficial ASCC were included. Median lesion size was 24 mm (range, 9-65 mm) and median procedure time was 62 minutes (range, 26-210 minutes). Accuracy of optical diagnosis using Japanese Endoscopic Society Intrapapillary capillary loops (IPCLs) classification to predict final histology was 63.6%. En bloc and R0 resection were achieved in 22 (95.6%) and 18 patients (78.3%), respectively. The curative resection rate was 73.9% (17/23). Three patients received additional complementary treatment. Delayed bleeding was observed in four patients (17.4%), two of whom required endoscopic hemostasis. Anal pain was reported in nine patients (39.1%) and was effectively managed with analgesics. Fecal incontinence and anal stenosis both occurred in one patient during the perioperative period. During median follow-up of 10.1 months (range, 0-69.6 months), no recurrences were observed. Conclusions ESD is a feasible and effective treatment for superficial ASCC. Adverse events were successfully managed with medical or endoscopic therapy. ESD should be considered as first-line resection technique to prevent recurrence while preserving anal sphincter function.
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页数:9
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