Abnormal expression of Hippo-YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps

被引：0

作者：

Yu, Xinyu ^{[1
]}

Kong, Weijia ^{[1
]}

Shang, Kaiyue ^{[1
]}

Xing, Hongxin ^{[1
]}

Sun, Wenjing ^{[2
]}

Li, Qianqian ^{[3
]}

Zhang, Hui ^{[1
]}

机构：

[1] Shandong First Med Univ, Shandong Prov Hosp, Dept Obstet & Gynaecol, Jinan 250021, Shandong, Peoples R China

[2] Shandong Univ, Shandong Prov Hosp 3, Cheeloo Coll Med, Dept Obstet & Gynaecol, Jinan, Peoples R China

[3] Shandong First Med Univ, Jinan Matern & Child Care Hosp, Dept Obstet & Gynaecol, Jinan, Peoples R China

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2025年 / 45卷 / 01期

关键词：

Hippo; YAP1; progesterone receptor; PRL; endometrial polyps; RECEPTOR EXPRESSION; ESTROGEN-RECEPTOR; ORGAN SIZE; YAP; CANCER;

D O I：

10.1080/01443615.2025.2533965

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BackgroundEndometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo-YAP1 signalling pathway has been studied in various diseases. However, few studies have explored their expression in EPs and association with progesterone resistance. Prolactin (PRL), a molecular marker of endometrial mesenchymal cell metaplasia, indirectly reflects progesterone action in vivo. This study aimed to explore the role of Hippo-YAP1 signalling pathway in EPs.MethodsEndometrial tissue specimens obtained by surgical resection from 35 patients with a normal endometrium and 35 with EPs were collected between July 2023 and July 2024. Immunohistochemically, the expressions of mammalian STE20-like kinase 1 (MST1), Yes-associated protein 1 (YAP1), progesterone receptor (PR) and PRL in the normal endometrium and EPs tissues were detected.ResultsCompared to normal endometrial tissues, the expression of MST1 was relatively low in EPs (p < .05), while the total and nuclear expression of YAP1 was relatively high in EPs (p < .0001). The expression of PR in EPs tissues was significantly lower than that in normal endometrial tissues (p < .05), and the expression level of PRL was lower than that of normal endometrium in EPs tissues (p < .001).ConclusionsEPs have progesterone resistance, and the Hippo-YAP1 signalling pathway may be involved in the development and progression of EPs by acting on the progesterone resistance mechanism.

引用

页数：11

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