Reduced circulating NrCAM as a biomarker for fetal growth restriction

被引：0

作者：

Bartho, Lucy A. ^{[1
,2
]}

Walker, Susan P. ^{[1
,2
]}

Idzes, Danica ^{[1
,2
]}

Heazell, Alexander E. P. ^{[4
,5
]}

Higgins, Lucy E. ^{[4
,5
]}

Sferruzzi-Perri, Amanda N. ^{[6
]}

Hannan, Natalie J. ^{[1
,3
]}

Cluver, Catherine A. ^{[1
,2
,7
]}

Bergman, Lina ^{[7
,8
,9
]}

Wong, Georgia P. ^{[1
,2
]}

Kandel, Manju ^{[1
,2
]}

Cannon, Ping ^{[1
,2
]}

Nguyen, Tuong-Vi ^{[1
,2
]}

Nguyen, Anna ^{[1
,2
]}

Tong, Stephen ^{[1
,2
]}

Kaitu'u-Lino, Tu'uhevaha J. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Translat Obstet Grp, 163 Studley Rd, Heidelberg, Vic 3084, Australia

[2] Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia

[3] Univ Melbourne, Mercy Hosp Women, Dept Obstet & Gynaecol, Therapeut Discovery & Vasc Funct Pregnancy Grp, 163 Studley Rd, Heidelberg, Vic 3084, Australia

[4] Univ Manchester, Fac Med & Human Sci, Maternal & Fetal Hlth Res Ctr, Div Dev Biol & Med, Manchester, England

[5] Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester, England

[6] Univ Cambridge, Ctr Trophoblast Res, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England

[7] Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa

[8] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden

[9] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden

来源：

EBIOMEDICINE | 2025年 / 118卷

基金：

英国医学研究理事会;

关键词：

NrCAM; Placenta; Hypoxia; Preeclampsia; FGR; Biomarker;

D O I：

10.1016/j.ebiom.2025.105854

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Placental insufficiency underpins pregnancy complications, fetal growth restriction (FGR) and preeclampsia, yet predictive biomarkers are limited. Neuronal Cell Adhesion Molecule (NrCAM) may be a promising biomarker of placental dysfunction. This study investigated whether NrCAM can predict diseases of placental insufficiency. Methods Circulating NrCAM was measured across independent cohorts. Plasma NrCAM was assessed at 36 weeks' gestation in women who later delivered FGR infants (<3rd centile birthweight), or developed preeclampsia at term. Circulating NrCAM was also measured in international cohorts: a UK high-risk cohort of women presenting with reduced fetal movements and delivered an FGR infant; a high-risk cohort from South Africa diagnosed with preeclampsia or eclampsia. NrCAM was also assessed in pregnancies with preterm FGR or preeclampsia (<34 weeks gestation). The effect of hypoxia on NrCAM expression was measured in trophoblast stem cells, primary trophoblasts, and a murine FGR model. Findings Circulating NrCAM was reduced at 36 weeks' gestation in women who later delivered FGR infants (p = 4.75 x 10(-6), AUC = 0.76, n = 26 FGR, n = 957 controls). In the UK cohort, reduced NrCAM levels were associated with FGR (p = 9.34 x 10(-3), AUC = 0.72, n = 12 FGR, n = 235 control). In the South Africa cohort, circulating NrCAM was reduced with preeclampsia (p = 0.03, AUC = 0.70, n = 27 preeclampsia, n = 15 control). Placental NrCAM expression was lower in FGR (p = 0.0003, n = 23 FGR) and preeclampsia (p = 0.0003, n = 41 preeclampsia, n = 20 controls). Hypoxia reduced NrCAM expression in human trophoblast stem cells (p < 0.01) primary trophoblasts (p < 0.0001) and in a murine FGR model (p < 0.01, n = 9 per group). Interpretation Reductions in plasma and placental NrCAM are strongly associated with FGR and may be driven by hypoxia.

引用

页数：14

共 36 条

[1]

ACOG. American College of Obstetricians and Gynecologists, 2013, Hypertension in pregnancy

[2] The Involvement of Cell Adhesion Molecules, Tight Junctions, and Gap Junctions in Human Placentation [J].